葡萄牙北部确诊感染新冠病毒的癌症患者的特征与死亡率

Characteristics and Mortality of Patients With Cancer Diagnosed With SARS-CoV-2 in Northern Portugal.

作者信息

Taveira-Barbosa José, Garcia Teresa, Lebre Ana, Fontes Filipa, Brandão Mariana, Calisto Rita, Turé Rubén, Bento Maria José, Lunet Nuno, Morais Samantha, Lopes-Conceição Luísa

机构信息

Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal;

Serviço de Epidemiologia, Instituto Português de Oncologia do Porto FG, EPE, Porto, Portugal.

出版信息

Anticancer Res. 2025 Apr;45(4):1749-1760. doi: 10.21873/anticanres.17555.

DOI:10.21873/anticanres.17555

PMID:40155032

Abstract

BACKGROUND/AIM: Patients with cancer have been found to be at higher risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which may negatively affect their prognosis. This study aimed to compare sociodemographic and clinical characteristics, as well as mortality, between cancer patients with and without SARS-CoV-2 infection.

PATIENTS AND METHODS

Patients with tumors of the esophagus, stomach, colon and rectum, pancreas, lung, skin-melanoma, breast, cervix, non-Hodgkin lymphoma, and leukemia diagnosed between March 2019 and March 2021, and followed at the Portuguese Oncology Institute of Porto (IPO-Porto) were identified. Patients with SARS-CoV-2 infection between March 2020 and September 2021 were compared to patients without infection. Vital status was assessed up to March 2024. Cox proportional hazards regression was used to estimate crude, age- and stage-adjusted hazard ratios (HRs) and 95% confidence intervals (95%CIs) for mortality.

RESULTS

During follow-up, one-third of patients who had SARS-CoV-2 died (. one-fourth), corresponding to an adjusted HR (95%CI) of 1.39 (1.03-1.88). Significantly higher adjusted HRs were observed for residents outside Porto's Metropolitan Area (HR=1.94, 95%CI=1.22-3.09), patients with lung cancer (HR=2.02, 95%CI=1.12-3.66) and patients with surgery as the first cancer treatment received at IPO-Porto (HR=2.00, 95%CI=1.08-3.74).

CONCLUSION

Cancer patients with SARS-CoV-2 infection had higher mortality compared to those without infection, and specific subgroups of patients at higher risk were identified.

摘要

背景/目的：已发现癌症患者感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的风险更高，这可能对其预后产生负面影响。本研究旨在比较感染和未感染SARS-CoV-2的癌症患者的社会人口统计学和临床特征以及死亡率。

患者与方法

确定了2019年3月至2021年3月期间在葡萄牙波尔图肿瘤研究所（IPO-波尔图）诊断并随访的食管癌、胃癌、结直肠癌、胰腺癌、肺癌、皮肤黑色素瘤、乳腺癌、宫颈癌、非霍奇金淋巴瘤和白血病患者。将2020年3月至2021年9月期间感染SARS-CoV-2的患者与未感染的患者进行比较。截至2024年3月评估生存状态。使用Cox比例风险回归来估计死亡率的粗风险比、年龄和分期调整后的风险比（HR）以及95%置信区间（95%CI）。

结果

在随访期间，感染SARS-CoV-2的患者中有三分之一死亡（未感染患者为四分之一），对应调整后的HR（95%CI）为1.39（1.03 - 1.88）。在波尔图大都市区以外的居民（HR = 1.94，95%CI = 1.22 - 3.09）、肺癌患者（HR = 2.02，95%CI = 1.12 - 3.66）以及在IPO-波尔图接受手术作为首次癌症治疗的患者（HR = 2.00，95%CI = 1.08 - 3.74）中观察到显著更高的调整后HR。