Atıcı Serkan, Güneşer Deniz, Kepenekli Eda, Söyletir Güner, Soysal Ahmet
Department of Pediatrics, Division of Pediatric Infectious Disease, Okan University School of Medicine, Aydınlı Yolu Cd. No:2, Tuzla/Istanbul, 34947, Turkey.
Department of Microbiology, Marmara University School of Medicine, Istanbul, Turkey.
BMC Pediatr. 2025 Mar 28;25(1):244. doi: 10.1186/s12887-025-05593-w.
Approximately 100 capsular serotypes of S. pneumonia have been identified according to the composition of their capsular polysaccharides, currently available vaccines do not cover many of these. Pneumococcal vaccination serotype coverage is essential for preventing noninvasive and invasive illnesses as well as asymptomatic carriage. We aimed to determine the serotype distribution and antimicrobial susceptibility pattern of pneumococcal clinical isolates in this study. We also analyzed the serotype coverage rates of PCV13, which is applied in the NIP, and PCV-15 and PCV20, which have been introduced recently.
This study is a retrospective surveillance of pneumococcal infections including invasive pneumococcal isolates (IPIs) and non-invasive pneumococcal isolates (non-IPIs).
A total of 420 isolates from 356 different patients aged 0-89 years were enrolled in the study. A total of 420 pneumococcal isolates were serotyped and 26 different serotypes were detected. Serotype 19 F was the most prevalent serotype (n = 96, 22.8%), followed by 6 A/B (n = 55, 13.1%), 23 F (n = 49, 11.6%), 3 (n = 22, 5.2%) and 19 A (n = 16, 3.8%).
Surveillance studies of pneumococcal diseases are critical to investigating current serotype distributions, antibiotic resistance status, and frequency of IPD cases. Considering the increasing antibiotic resistance rates of S. pneumoniae, it is necessary to provide protective immunization by switching to more comprehensive PCV vaccines rather than treatment.
Not applicable.
根据肺炎链球菌荚膜多糖的组成，已鉴定出约100种荚膜血清型，目前可用的疫苗并未涵盖其中许多血清型。肺炎球菌疫苗血清型覆盖率对于预防非侵袭性和侵袭性疾病以及无症状携带至关重要。在本研究中，我们旨在确定肺炎球菌临床分离株的血清型分布和抗菌药敏模式。我们还分析了国家免疫规划中应用的13价肺炎球菌结合疫苗（PCV13）以及最近引入的15价肺炎球菌结合疫苗（PCV-15）和20价肺炎球菌结合疫苗（PCV20）的血清型覆盖率。
本研究是一项对肺炎球菌感染的回顾性监测，包括侵袭性肺炎球菌分离株（IPIs）和非侵袭性肺炎球菌分离株（非IPIs）。
本研究共纳入了来自356名年龄在0至89岁不同患者的420株分离株。共对420株肺炎球菌分离株进行了血清分型，检测到26种不同的血清型。19F血清型是最常见的血清型（n = 96，22.8%），其次是6A/B（n = 55，13.1%）、23F（n = 49，11.6%）、3（n = 22，5.2%）和19A（n = 16，3.8%）。
肺炎球菌疾病的监测研究对于调查当前血清型分布、抗生素耐药状况和侵袭性肺炎球菌病（IPD）病例频率至关重要。考虑到肺炎链球菌抗生素耐药率不断上升，有必要通过改用更全面的肺炎球菌结合疫苗来提供保护性免疫，而不是进行治疗。
不适用。
