Leyva Hannah, Fanikos John, Lan Zhou, Scimeca Giovanni, Bikdeli Behnood, Piazza Gregory, Goldhaber Samuel Z
Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Thrombosis Research Group, Harvard Medical School, Boston, Mass.
North American Thrombosis Forum-Vasculearn Network, Brookline, Mass.
Am J Med. 2025 Sep;138(9):1185-1196. doi: 10.1016/j.amjmed.2025.03.020. Epub 2025 Mar 28.
Venous thromboembolism is a complication of major orthopedic surgeries such as hip fracture repair, total knee arthroplasty, and total hip arthroplasty. Prophylaxis against venous thromboembolism reduces the risk of pulmonary embolism and deep vein thrombosis associated with these procedures. Aspirin is widely prescribed for venous thromboembolism prophylaxis in major orthopedic surgery. We review the epidemiology of hip fracture, total knee arthroplasty, and total hip arthroplasty, and describe aspirin's mechanisms of action, efficacy, and safety.
静脉血栓栓塞是髋部骨折修复、全膝关节置换术和全髋关节置换术等大型骨科手术的一种并发症。预防静脉血栓栓塞可降低与这些手术相关的肺栓塞和深静脉血栓形成的风险。阿司匹林在大型骨科手术中被广泛用于预防静脉血栓栓塞。我们回顾了髋部骨折、全膝关节置换术和全髋关节置换术的流行病学，并描述了阿司匹林的作用机制、疗效和安全性。
