Jia Xiaohui, Dong Yuhe, Lu Jihui, Yang Zhenyuan, Xu Ran, Zhang Xiang, Jiao Jingyi, Zhang Zixuan, Lin Yixuan, Chu Fuhao, Wang Penglong, Zhong Tian, Lei Haimin
School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macao 999078, China.
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.
Int J Pharm. 2025 Apr 30;675:125529. doi: 10.1016/j.ijpharm.2025.125529. Epub 2025 Mar 28.
On-demand responsive hydrogels are a promising solution for effective wound management as they can adjust their properties in response to changes in the wound environment, allowing them to provide tailored support for the healing process. However, the conventional hydrogels may not fully meet the diverse demands of the intricate healing process. Herein, a novel glycyrrhizic acid (GA) based self-assembly hydrogel coordinated with copper and polyphenol (GCP hydrogel) was developed to exhibit triggered release behavior in response to the microenvironment. The GCP hydrogel coordinated with copper and protocatechuic acid (PA) and self-assembled with GA, also exhibits enzyme-like properties by mimicking the cascade process of superoxide dismutase (SOD) and catalase (CAT), effectively scavenging reactive oxygen species (ROS). Furthermore, the on-demand release of Cu at different stages of the wound healing process can not only enhance the antibacterial ability of methicillin-resistant Staphylococcus aureus (MRSA) but also intelligently promote angiogenesis with outstanding biocompatibility. In addition, the GCP hydrogel effectively modulated the activity of macrophages in response to inflammatory stimuli, exhibiting remarkable anti-inflammatory abilities and promoting tissue regeneration. The multifunctional GCP hydrogel platform has the potential to create a dynamic microenvironment that is conducive to tissue regeneration, making it an ideal candidate for smart wound management.
按需响应水凝胶是有效伤口管理的一种有前景的解决方案，因为它们可以根据伤口环境的变化调整其性能，从而为愈合过程提供量身定制的支持。然而，传统水凝胶可能无法完全满足复杂愈合过程的多样化需求。在此，开发了一种新型的基于甘草酸（GA）与铜和多酚配位的自组装水凝胶（GCP水凝胶），以表现出对微环境的触发释放行为。与铜和原儿茶酸（PA）配位并与GA自组装的GCP水凝胶，还通过模拟超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的级联过程表现出类酶特性，有效清除活性氧（ROS）。此外，在伤口愈合过程的不同阶段按需释放铜不仅可以增强耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌能力，还能以出色的生物相容性智能地促进血管生成。此外，GCP水凝胶在炎症刺激下有效调节巨噬细胞的活性，表现出显著的抗炎能力并促进组织再生。多功能GCP水凝胶平台有潜力创造一个有利于组织再生的动态微环境，使其成为智能伤口管理的理想候选者。
