Zhang Xu, Wu Zhi Meng, Zhang Lu, Xin Bing Long, Wang Xiang Rui, Lu Xin Lan, Lu Gui Fang, Ren Mu Dan, He Shui Xiang, Li Ya Rui
Department of Gastroenterology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China;Shannxi clinical research center of digestive disease (cancer division), Xi'an 710061, Shaanxi, China.
Shannxi clinical research center of digestive disease (cancer division), Xi'an 710061, Shaanxi, China;Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Biomed Environ Sci. 2025 Feb 20;38(2):167-177. doi: 10.3967/bes2024.142.
Several epidemiological observational studies have related particulate matter (PM) exposure to Inflammatory bowel disease (IBD), but many confounding factors make it difficult to draw causal links from observational studies. The objective of this study was to explore the causal association between PM exposure, its absorbance, and IBD.
We assessed the association of PM and PM absorbance with the two primary forms of IBD (Crohn's disease [CD] and ulcerative colitis [UC]) using Mendelian randomization (MR) to explore the causal relationship. We conducted two-sample MR analyses with aggregated data from the UK Biobank genome-wide association study. Single-nucleotide polymorphisms linked with PM concentrations or their absorbance were used as instrumental variables (IVs). We used inverse variance weighting (IVW) as the primary analytical approach and four other standard methods as supplementary analyses for quality control.
The results of MR demonstrated that PM had an adverse influence on UC risk (odds ratio [ ] = 1.010; 95% confidence interval [ ] = 1.001-1.019, = 0.020). Meanwhile, the results of IVW showed that PM absorbance was also causally associated with UC ( = 1.012; 95% = 1.004-1.019, = 0.002). We observed no causal relationship between PM , PM absorbance, and CD. The results of sensitivity analysis indicated the absence of heterogeneity or pleiotropy, ensuring the reliability of MR results.
Based on two-sample MR analyses, there are potential positive causal relationships between PM , PM absorbance, and UC.
多项流行病学观察性研究已将颗粒物（PM）暴露与炎症性肠病（IBD）联系起来，但许多混杂因素使得难以从观察性研究中得出因果关系。本研究的目的是探讨PM暴露、其吸光度与IBD之间的因果关联。
我们使用孟德尔随机化（MR）来评估PM及其吸光度与IBD的两种主要形式（克罗恩病[CD]和溃疡性结肠炎[UC]）之间的关联，以探索因果关系。我们利用来自英国生物银行全基因组关联研究的汇总数据进行了两样本MR分析。与PM浓度或其吸光度相关的单核苷酸多态性被用作工具变量（IV）。我们采用逆方差加权（IVW）作为主要分析方法，并使用其他四种标准方法作为补充分析以进行质量控制。
MR结果表明，PM对UC风险有不利影响（优势比[OR]=1.010；95%置信区间[CI]=1.001-1.019，P=0.020）。同时，IVW结果显示，PM吸光度也与UC存在因果关联（OR=1.012；95%CI=1.004-1.019，P=0.002）。我们未观察到PM、PM吸光度与CD之间存在因果关系。敏感性分析结果表明不存在异质性或多效性，确保了MR结果的可靠性。
基于两样本MR分析，PM、PM吸光度与UC之间存在潜在的正向因果关系。
