Cao Zixuan, Gao Tingting, Bajinka Ousman, Zhang Yali, Yuan Xingxing
Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China.
Country School of Medicine and Allied Health Sciences, University of The Gambia, Banjul, Gambia.
Front Med (Lausanne). 2025 Mar 14;12:1523870. doi: 10.3389/fmed.2025.1523870. eCollection 2025.
Recently, microbiome medicine has attracted the attention of researchers. While this rapidly growing medical approach for various diseases and disorders is changing the paradigm, it is imperative to weigh both its benefits and the associated risk factors. For instance, manipulation of the gut microbiota (GM) has positive effects on metabolic and neurodegenerative diseases. Notably, fecal microbiota transplantation (FMT), a complex method, has shown promise; however, many doubt its feasibility without adverse effects on human health. Given the number of human clinical trials investigating FMT for the treatment of various disorders, this review summarizes recent findings on its impact on human health. This review summarizes the metabolic responses associated with FMT and their reversal effects on gastrointestinal infections, behavioral changes, and immune responses. Additionally, this review discusses the role of FMT in antimicrobial resistance and its co-supplementation effects on human health, safety, potential risks, limitations, prospects, and recommendations. Although this review does not cover all the studies in the database, the searched terms for FMT and human health in clinical trials are sufficient to provide a summary of the current perspective.
最近，微生物组医学已引起研究人员的关注。虽然这种针对各种疾病和病症迅速发展的医学方法正在改变范式，但权衡其益处和相关风险因素势在必行。例如，肠道微生物群（GM）的调控对代谢性疾病和神经退行性疾病具有积极影响。值得注意的是，粪便微生物群移植（FMT）这种复杂方法已显示出前景；然而，许多人怀疑其在不对人类健康产生不利影响的情况下的可行性。鉴于有大量针对FMT治疗各种病症的人体临床试验，本综述总结了其对人类健康影响的最新研究结果。本综述总结了与FMT相关的代谢反应及其对胃肠道感染、行为变化和免疫反应的逆转作用。此外，本综述讨论了FMT在抗菌耐药性中的作用及其对人类健康、安全性、潜在风险、局限性、前景和建议的联合补充效应。虽然本综述未涵盖数据库中的所有研究，但在临床试验中搜索FMT和人类健康的术语足以提供当前观点的总结。
