Department of Hygiene Inspection & Quarantine Science, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Department of Hygiene Inspection & Quarantine Science, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Biochem Biophys Res Commun. 2024 Nov 12;733:150580. doi: 10.1016/j.bbrc.2024.150580. Epub 2024 Aug 22.
Colorectal cancer (CRC) is the third most common cancer in the world. With the development of high-throughput gene sequencing technology, homeostasis imbalance of the intestinal microbiota has been proven to play a key role in the pathogenesis of CRC. Furthermore, fecal bacteria transplantation (FMT) has been shown to alter the intestinal microecology, and is potentially an effective treatment for CRC. Sodium selenite plays an important role in anticancer adjuvant therapy due to its high pro-oxidation characteristics. In this study, a murine CRC tumor model was induced by AOM/DSS, and CRC mice were treated by FMT, sodium selenite, and FMT combined with sodium selenite. The results showed that FMT, sodium selenite, and FMT combined with sodium selenite inhibited the occurrence of CRC in mice, increased the abundance of beneficial intestinal bacteria, produced different microorganisms, and changed the metabolic pathways of the intestinal microbiota. In summary, FMT, sodium selenite, and FMT combined with sodium selenite can inhibit the occurrence of CRC by increasing the abundance of beneficial bacteria and regulating phenotypes and metabolic pathways. Notably, the effect of FMT combined with sodium selenite in reducing the number of tumors, protecting intestinal tissues, and restoring the diversity and richness of the intestinal microbiota is superior to that of FMT alone or sodium selenite alone. The results of this study provide new ideas for the application of FMT and selenium in the treatment of CRC.
结直肠癌（CRC）是世界上第三大常见癌症。随着高通量基因测序技术的发展，肠道微生物群的平衡失调被证明在 CRC 的发病机制中起关键作用。此外，粪便细菌移植（FMT）已被证明可以改变肠道微生态，并且可能是 CRC 的有效治疗方法。亚硒酸钠由于其高促氧化特性，在抗癌辅助治疗中发挥着重要作用。在本研究中，通过 AOM/DSS 诱导小鼠 CRC 肿瘤模型，并用 FMT、亚硒酸钠和 FMT 联合亚硒酸钠对 CRC 小鼠进行治疗。结果表明，FMT、亚硒酸钠和 FMT 联合亚硒酸钠抑制了小鼠 CRC 的发生，增加了有益肠道细菌的丰度，产生了不同的微生物，并改变了肠道微生物群的代谢途径。总之，FMT、亚硒酸钠和 FMT 联合亚硒酸钠通过增加有益细菌的丰度和调节表型和代谢途径来抑制 CRC 的发生。值得注意的是，FMT 联合亚硒酸钠在减少肿瘤数量、保护肠道组织和恢复肠道微生物群的多样性和丰富度方面的效果优于单独使用 FMT 或亚硒酸钠。本研究结果为 FMT 和硒在 CRC 治疗中的应用提供了新的思路。
