Thompson T E, Allietta M, Brown R E, Johnson M L, Tillack T W
Biochim Biophys Acta. 1985 Jul 25;817(2):229-37. doi: 10.1016/0005-2736(85)90024-0.
Molecules of the ganglioside GM1 are randomly distributed in liquid-crystalline 1-palmitoyl-2-oleoyl phosphatidylcholine bilayers. This conclusion is based on a freeze-etch electron microscopic study using ferritin-conjugated cholera toxin and cholera toxin alone as ganglioside labels. The average number of GM1 molecules under a label is calculated by a novel method from the dependence of the fraction of bilayer area covered by the label on the mole fraction of GM1 in the bilayer.
神经节苷脂GM1分子随机分布于液晶态的1-棕榈酰-2-油酰磷脂酰胆碱双分子层中。这一结论基于一项冷冻蚀刻电子显微镜研究，该研究使用铁蛋白偶联霍乱毒素以及单独使用霍乱毒素作为神经节苷脂标记物。通过一种新方法，根据标记物覆盖的双分子层面积分数对双分子层中GM1摩尔分数的依赖性，计算出一个标记物下GM1分子的平均数量。
