• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

铕离子浓度对作为生物医学中多功能光磁探针的取向氧化钆/十六烷基三甲基溴化铵纳米粒子光学和磁性能的影响。

Effect of Eu ion concentration on optical and magnetic properties of oriented GdO/CTAB nanoparticles as multifunctional optical-magnetic probes in biomedicine.

作者信息

Pham Thi Lien, Tong Cong Quang, Vu Ngoc Phan, Vu Thi Hong Ha, Ho Thi Anh, Pham Duc Thang, Le Thi Hoi, Dinh Manh Tien, Nguyen Thanh Huong, Hoang Thi Khuyen, Lam Thi Kieu Giang, Nguyen Vu, Pham Hong Nam, Le Tien Ha

机构信息

Institute of Materials Science, Vietnam Academy of Science and Technology 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam.

Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University Hanoi 12116 Vietnam

出版信息

RSC Adv. 2025 Mar 28;15(12):9521-9533. doi: 10.1039/d5ra00932d. eCollection 2025 Mar 21.

DOI:10.1039/d5ra00932d
PMID:40161524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11951096/
Abstract

The GdO:Eu nanoparticles were synthesized using a multi-step chemical method with urea as a reactant to control the ratio of different Eu activation centers: 2, 4, 6, 8, 10, and 12 mol% combined with CTAB surfactant to improve surface quality. The study aimed to determine the optimal concentration of Eu in the presence of CTAB to increase biocompatibility and achieve the best fluorescence. The structure, surface morphology, optical properties, and magnetic properties of the materials were analyzed through FSEM, XRD, HRTEM, XPS, UV-vis, fluorescence, fluorescence excitation, time-resolved fluorescence, vibrating sample magnetometry (VSM), and magnetic heating measurements. The obtained material had a diameter of 180-280 nm, and it emitted red light with characteristic shifts from D to F ( = 0-4). The strongest emission peak occurred at the transition of D to F, corresponding to a wavelength of 611 nm. The crystal is in the cubic phase. The highest lifetime of the samples is 2.1 ms, and the highest calculated quantum efficiency is 91% for the GdO:8% Eu sample. The M-H hysteresis curve revealed that the highest magnetic field obtained was 1.83 emu g. Experimental induction heating of samples reached temperatures in the range of 44-49 °C, which is an appropriate temperature range for destroying cancer cells without affecting healthy cells. These findings demonstrate that the material has great potential in cancer diagnosis and treatment.

摘要

采用多步化学方法，以尿素为反应物合成了GdO:Eu纳米颗粒，以控制不同Eu激活中心的比例：2%、4%、6%、8%、10%和12%，并结合CTAB表面活性剂以改善表面质量。该研究旨在确定在CTAB存在下Eu的最佳浓度，以提高生物相容性并实现最佳荧光。通过场发射扫描电子显微镜（FSEM）、X射线衍射（XRD）、高分辨率透射电子显微镜（HRTEM）、X射线光电子能谱（XPS）、紫外可见光谱、荧光光谱、荧光激发光谱、时间分辨荧光光谱、振动样品磁强计（VSM）和磁热测量对材料的结构、表面形貌、光学性质和磁性进行了分析。所获得的材料直径为180 - 280 nm，发出从D到F（J = 0 - 4）具有特征性位移的红光。最强发射峰出现在D到F的跃迁处，对应波长为611 nm。该晶体为立方相。样品的最高寿命为2.1 ms，对于GdO:8% Eu样品，计算得到的最高量子效率为91%。M - H磁滞回线显示获得的最高磁场为1.83 emu g。对样品进行实验感应加热达到的温度范围为44 - 49°C，这是一个在不影响健康细胞的情况下破坏癌细胞的合适温度范围。这些发现表明该材料在癌症诊断和治疗方面具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/ae683d12e392/d5ra00932d-f17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/41257149633b/d5ra00932d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/caa83f9d2457/d5ra00932d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/6e3d6a9d156f/d5ra00932d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/acd92f6d6823/d5ra00932d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/8795a1797499/d5ra00932d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/b4623e5671ac/d5ra00932d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/c2d9a51768d4/d5ra00932d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/362400cb8008/d5ra00932d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/0188ce0f50da/d5ra00932d-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/adb47ec0a12c/d5ra00932d-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/680fbb1f6148/d5ra00932d-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/5d4a3be8aa2c/d5ra00932d-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/064531de7832/d5ra00932d-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/a20151e90e19/d5ra00932d-f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/deb047911f14/d5ra00932d-f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/1a44f61ae8a1/d5ra00932d-f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/c425d1b72bb8/d5ra00932d-f16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/ae683d12e392/d5ra00932d-f17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/41257149633b/d5ra00932d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/caa83f9d2457/d5ra00932d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/6e3d6a9d156f/d5ra00932d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/acd92f6d6823/d5ra00932d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/8795a1797499/d5ra00932d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/b4623e5671ac/d5ra00932d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/c2d9a51768d4/d5ra00932d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/362400cb8008/d5ra00932d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/0188ce0f50da/d5ra00932d-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/adb47ec0a12c/d5ra00932d-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/680fbb1f6148/d5ra00932d-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/5d4a3be8aa2c/d5ra00932d-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/064531de7832/d5ra00932d-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/a20151e90e19/d5ra00932d-f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/deb047911f14/d5ra00932d-f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/1a44f61ae8a1/d5ra00932d-f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/c425d1b72bb8/d5ra00932d-f16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb3a/11951096/ae683d12e392/d5ra00932d-f17.jpg

相似文献

1
Effect of Eu ion concentration on optical and magnetic properties of oriented GdO/CTAB nanoparticles as multifunctional optical-magnetic probes in biomedicine.铕离子浓度对作为生物医学中多功能光磁探针的取向氧化钆/十六烷基三甲基溴化铵纳米粒子光学和磁性能的影响。
RSC Adv. 2025 Mar 28;15(12):9521-9533. doi: 10.1039/d5ra00932d. eCollection 2025 Mar 21.
2
Synthesis of Gd2O3:Eu nanoplatelets for MRI and fluorescence imaging.用于磁共振成像和荧光成像的Gd2O3:Eu纳米片的合成
Nanoscale Res Lett. 2015 May 13;10:215. doi: 10.1186/s11671-015-0905-4. eCollection 2015.
3
Radiopharmaceutical and Eu doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery.放射性药物和 Eu 掺杂氧化钆纳米粒子介导的三重激发荧光成像及图像引导手术。
J Nanobiotechnology. 2021 Jul 16;19(1):212. doi: 10.1186/s12951-021-00920-6.
4
[Preparation and luminescence properties of nanocrystals Gd2O3: Eu3+].纳米晶体Gd2O3:Eu3+的制备及发光特性
Guang Pu Xue Yu Guang Pu Fen Xi. 2007 Mar;27(3):427-31.
5
[Study on spectroscopic properties of Eu and Tb mixed solid complexes with a diamide ligand].含二酰胺配体的铕和铽混合固体配合物的光谱性质研究
Guang Pu Xue Yu Guang Pu Fen Xi. 2008 Aug;28(8):1856-61.
6
[Preparation of nanocrystal Gd2O3: Eu by EDTA complexing sol-gel process and spectroscopic study].通过乙二胺四乙酸络合溶胶-凝胶法制备纳米晶Gd2O3:Eu及其光谱研究
Guang Pu Xue Yu Guang Pu Fen Xi. 2003 Apr;23(2):236-9.
7
Morphology- and size-dependent spectroscopic properties of Eu-doped GdO colloidal nanocrystals.铕掺杂氧化钆胶体纳米晶体的形貌和尺寸依赖性光谱性质
J Nanopart Res. 2014;16(11):2690. doi: 10.1007/s11051-014-2690-x. Epub 2014 Oct 18.
8
Optical behaviors of Mn-modified cubic type ZnTiO:Eu nanocrystals: Application in optical thermometers based on fluorescence intensity ratio and lifetime.锰改性立方型ZnTiO:Eu纳米晶体的光学行为：基于荧光强度比和寿命的光学温度计中的应用。
Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 5;304:123339. doi: 10.1016/j.saa.2023.123339. Epub 2023 Sep 1.
9
Multicolor tunable luminescence and energy transfer of core-shell structured SiO@GdO microspheres co-activated with Dy/Eu under single UV excitation.在单一紫外激发下，Dy/Eu共激活的核壳结构SiO@GdO微球的多色可调发光及能量转移
Dalton Trans. 2020 Jun 14;49(22):7397-7405. doi: 10.1039/d0dt00735h. Epub 2020 May 19.
10
Investigation of Upconversion, downshifting and quantum -cutting behavior of Eu, Yb, Bi co-doped LaNbO phosphor as a spectral conversion material.研究 Eu、Yb、Bi 共掺杂 LaNbO 荧光粉的上转换、下转换和量子剪裁行为作为光谱转换材料。
Methods Appl Fluoresc. 2018 Apr 4;6(3):035001. doi: 10.1088/2050-6120/aab253.

本文引用的文献

1
Synthesis of gadolinium oxide nanodisks and gadolinium doped iron oxide nanoparticles for MR contrast agents.用于磁共振造影剂的氧化钆纳米盘和钆掺杂氧化铁纳米颗粒的合成。
J Mater Chem B. 2017 Jan 21;5(3):418-422. doi: 10.1039/c6tb02854c. Epub 2016 Dec 21.
2
Multifunctional Gd,Ce,Tb co-doped β-tricalcium phosphate porous nanospheres for sustained drug release and bioimaging.用于持续药物释放和生物成像的多功能钆、铈、铽共掺杂β-磷酸三钙多孔纳米球
J Mater Chem B. 2016 Jun 14;4(22):3903-3910. doi: 10.1039/c5tb02767e. Epub 2016 May 13.
3
Rapid, microwave-assisted synthesis of GdO and Eu:GdO nanocrystals: characterization, magnetic, optical and biological studies.
氧化钆及铕掺杂氧化钆纳米晶体的快速微波辅助合成：表征、磁性、光学及生物学研究
J Mater Chem B. 2014 Sep 14;2(34):5585-5593. doi: 10.1039/c4tb00763h. Epub 2014 Jul 24.
4
Spectroscopic analysis of alkaline-earth metal (Mg, Ca, Sr and Ba) co-doped GdO:Eu phosphors synthesized via co-precipitation route.通过共沉淀法合成的碱土金属（镁、钙、锶和钡）共掺杂氧化钆：铕荧光粉的光谱分析
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 15;231:118078. doi: 10.1016/j.saa.2020.118078. Epub 2020 Jan 17.
5
Gadolinium-based contrast agents - review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients.基于钆的造影剂——关于磁共振成像信号强度变化和组织沉积的近期文献综述，重点关注儿科患者。
Pediatr Radiol. 2019 Apr;49(4):448-457. doi: 10.1007/s00247-018-4304-8. Epub 2019 Mar 29.
6
Gadolinium deposition and the potential for toxicological sequelae - A literature review of issues surrounding gadolinium-based contrast agents.钆沉积与潜在的毒理学后果——围绕基于钆的造影剂的问题文献综述。
Br J Clin Pharmacol. 2018 Nov;84(11):2522-2534. doi: 10.1111/bcp.13718. Epub 2018 Aug 17.
7
Nanotechnology: a promising method for oral cancer detection and diagnosis.纳米技术：口腔癌检测和诊断的有前途的方法。
J Nanobiotechnology. 2018 Jun 11;16(1):52. doi: 10.1186/s12951-018-0378-6.
8
Functionalized rare earth-doped nanoparticles for breast cancer nanodiagnostic using fluorescence and CT imaging.功能化的稀土掺杂纳米粒子用于乳腺癌的荧光和 CT 成像纳米诊断。
J Nanobiotechnology. 2018 Mar 22;16(1):26. doi: 10.1186/s12951-018-0359-9.
9
MRI contrast agents: Classification and application (Review).磁共振成像造影剂：分类与应用（综述）
Int J Mol Med. 2016 Nov;38(5):1319-1326. doi: 10.3892/ijmm.2016.2744. Epub 2016 Sep 21.
10
Bifunctional Luminomagnetic Rare-Earth Nanorods for High-Contrast Bioimaging Nanoprobes.双功能发光磁性稀土纳米棒用于高对比度生物成像纳米探针。
Sci Rep. 2016 Sep 2;6:32401. doi: 10.1038/srep32401.