Rojas-Vargas Jorge, Wilcox Hannah, Monari Bern, Gajer Pawel, Zuanazzi David, Shouldice Ainslie, Parmar Reeya, Haywood Priscilla, Tai Vera, Krakowsky Yonah, Potter Emery, Ravel Jacques, Prodger Jessica L
bioRxiv. 2025 Mar 15:2025.03.14.643288. doi: 10.1101/2025.03.14.643288.
Transfeminine people (assigned male at birth) often undergo penile inversion vaginoplasty to create vulva, a clitoris and a vaginal canal (referred to as a neovagina). After vaginoplasty, transfeminine people frequently experience gynecological concerns but their etiology is unknown due to a lack of knowledge of the neovaginal microenvironment. We characterized neovaginal microbiota and cytokines in 47 transfeminine participants. Participants self-reported sexual behaviors and symptoms, enabling correlation with bacterial (16S rRNA) and immune profiles. Four distinct clusters of co-occurring bacteria with unique immune profiles were identified. One cluster, which included , , and , was abundant, stable, and correlated with lower cytokines. Conversely, another cluster containing , , , and was linked to higher cytokines. Although was detected, -dominance was rare. These findings underscore the need for evidence-based clinical guidelines tailored to transfeminine gynecologic care, emphasizing the vital role of the neovaginal microbiome in symptom management and sexual health.
跨性别女性（出生时被指定为男性）通常会接受阴茎倒置阴道成形术来打造外阴、阴蒂和阴道管（称为新阴道）。阴道成形术后，跨性别女性经常会出现妇科问题，但由于对新阴道微环境缺乏了解，其病因尚不清楚。我们对47名跨性别女性参与者的新阴道微生物群和细胞因子进行了特征分析。参与者自行报告性行为和症状，以便与细菌（16S rRNA）和免疫谱进行关联。识别出了四个具有独特免疫谱的共生细菌不同簇。其中一个簇包括……、……和……，数量丰富、稳定，且与较低的细胞因子相关。相反，另一个包含……、……、……和……的簇与较高的细胞因子有关。虽然检测到了……，但以……为主导的情况很少见。这些发现强调了需要有针对跨性别女性妇科护理的循证临床指南，强调新阴道微生物群在症状管理和性健康中的重要作用。
