心肌间质的固定电荷
Fixed charges of the heart muscle interstitium.
作者信息
Parent L, Caillé J P
出版信息
Biophys J. 1985 May;47(5):725-9. doi: 10.1016/S0006-3495(85)83970-9.
The interstitium of the heart muscle is primarily composed of ground substance. The glycoproteins and proteoglycans that formed the ground substance bore negative charges at neutral pH like the glycosaminoglycans and proteoglycans of the water-rich phase of the interstitium. Microelectrodes were used to look for the existence of an electrical potential between the interstitium of the rabbit papillary muscle and an ambient medium. Evidence is presented for the existence of such an electrical potential. When the ambient solution was a Krebs solution, this potential was evaluated at -5.7 mV. This electrical potential is dependent on the filling solution of the microelectrodes and on the ambient medium; in rabbit serum, the electrical potential diminished to -0.6 mV. Assuming that this potential is a measure of the Donnan potential, the Cl and Na activities in the interstitium were evaluated to 76 and 135 mM when the rabbit papillary muscle was superfused with a Kreb's solution.
心肌间质主要由细胞外基质组成。构成细胞外基质的糖蛋白和蛋白聚糖在中性pH下带有负电荷，就像间质富水相中的糖胺聚糖和蛋白聚糖一样。使用微电极来寻找兔乳头肌间质与周围介质之间是否存在电势。有证据表明存在这种电势。当周围溶液为 Krebs 溶液时，该电势评估为 -5.7 mV。这种电势取决于微电极的填充溶液和周围介质；在兔血清中，电势降至 -0.6 mV。假设该电势是唐南电势的一种度量，当兔乳头肌用 Krebs 溶液灌注时，间质中的 Cl 和 Na 活性评估为 76 和 135 mM。
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