Kwong Fong Lien, Pounds Rachel, Farah Yasmin, Yap Jason K W
Pan Birmingham Gynaecological Cancer Centre, Midland Metropolitan Hospital, Sandwell and West Birmingham NHS Trust, Birmingham, UK.
School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
BJOG. 2025 Jul;132(8):1156-1165. doi: 10.1111/1471-0528.18156. Epub 2025 Mar 31.
To (i) evaluate the surgical morbidity, (ii) identify correlates of these and, (iii) explore whether flap reconstruction following vulvectomy improves patient symptoms and quality of life.
Single arm prospective study.
Single tertiary vulval centre, UK.
Consecutive cases of women undergoing radical vulvectomy and flap reconstructions for benign and (pre)invasive vulval conditions.
Prospective data collection from April 2020-February 2024. All women were given two validated questionnaires preoperatively and at 3-, 6- and 12-months to evaluate their satisfaction with the aesthetic, genitourinary and psychosexual outcomes.
Early and late complications within 30 days. Patient reported outcome measures preoperatively and post-reconstruction.
136 flaps in 69 women were analysed. 92.6% (126/136) and 83.1% (113/136) flaps developed none-to-mild complications at 7 days, and between days 8 to 30, respectively. Five necrotic flaps in two patients were surgically debrided. All flaps had healed/healing at 30 days. We did not identify any correlates of complications. At 12 months, women reported an improvement in genital symptoms (p < 0.001). 80.4% (37/46) reported no urinary incontinence vs. 48.1% (26/54) preoperatively, p = 0.0038. 24.4% (11/45) were sexually active vs. 9.3% (5/54) preoperatively, p = 0.0410. More women felt attractive (p = 0.0498), were satisfied with their body (p = 0.0407) and comfortable in intimate situations (p = 0.0273). 88.9% (40/45) stated that reconstruction helped with acceptance of their cancer diagnosis and surgery.
Locoregional flap reconstruction has low surgical morbidity, leads to a significant improvement in genitourinary and psychosexual functions. In women with cancer, reconstruction supports women to cope with their diagnosis.
