Dilaghi Emanuele, Esposito Gianluca, Franchellucci Gianluca, Annibale Bruno, Zullo Angelo
Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Minerva Gastroenterol (Torino). 2025 Jun;71(2):132-139. doi: 10.23736/S2724-5985.25.03861-6. Epub 2025 Mar 31.
Helicobacter pylori (H. pylori) infection is the main cause of the most frequent gastroduodenal diseases and gastric atrophy, with or without intestinal metaplasia, which predisposes to gastric cancer development. Gastric juice analysis may be useful in diagnosing these conditions, revealing the H. pylori infection and hypochlorhydria status by measuring ammonium concentrations and pH levels. EndoFaster is a device introduced to perform these analyses on gastric juice in real-time. The available data showed very high negative predictive values in ruling out the infection and corpus atrophic gastritis, thereby potentially reducing the need for gastric biopsies when test results are negative. This review aims to assess the potential role of EndoFaster in supporting the diagnosis of H. pylori infection, detecting gastric precancerous lesions, and other specific clinical applications, potentially reducing unnecessary gastric biopsies.
幽门螺杆菌（H. pylori）感染是最常见的胃十二指肠疾病以及胃萎缩（无论有无肠化生）的主要病因，而胃萎缩会增加胃癌发生的风险。胃液分析可能有助于诊断这些病症，通过测量铵浓度和pH值来揭示幽门螺杆菌感染和胃酸过少的状况。EndoFaster是一种用于实时对胃液进行这些分析的设备。现有数据显示，在排除感染和胃体萎缩性胃炎方面，其阴性预测值非常高，因此当检测结果为阴性时，可能会减少胃活检的必要性。本综述旨在评估EndoFaster在支持幽门螺杆菌感染诊断、检测胃癌前病变以及其他特定临床应用方面的潜在作用，可能减少不必要的胃活检。
