Fu Chengfeng, Shi Junwei, Haroon Muhammad, Luo Jing, Hu Ying, Jiang Depeng
Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China; Respiratory and Critical Care Medicine, The Second People's Hospital of Banan District, Chongqing, 400054, China.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023, China.
J Acad Nutr Diet. 2025 Sep;125(9):1275-1286.e3. doi: 10.1016/j.jand.2025.03.012. Epub 2025 Mar 29.
Copper plays a vital role in human physiological functions. However, limited epidemiologic evidence exists for an association between dietary copper intake and chronic obstructive pulmonary disease (COPD).
This study aimed to assess the association between dietary copper intake and COPD in American adults.
This cross-sectional study used data from the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018.
PARTICIPANTS/SETTING: Following the inclusion criteria, data from a total of 39 644 adults aged 20 and older were included in this study, out of which 3159 individuals had been diagnosed with COPD by a health care provider.
Dietary data were obtained through 24-hour dietary recall, and COPD diagnosis information was derived from a standardized medical condition questionnaire.
Multivariable logistic regression analysis was conducted to explore the association between dietary copper intake and COPD. To assess the dose-response relationship, a 3-piecewise restricted cubic spline analysis was employed. Potential thresholds were identified with a 2-piecewise logistic regression model. Subgroup analysis was performed to assess heterogeneity and explore potential interactions.
Compared with individuals in the lowest tertile of dietary copper intake (T1, <0.89 mg/day), those in the highest tertile (T3, >1.35 mg/day) had an adjusted odds ratio (OR) of 0.79 for COPD (95% confidence interval [CI], 0.68-0.92, P = .002). The relationship between dietary copper intake and COPD followed a nonlinear L-shaped curve (P < .001). Threshold analysis found a statistically significant inverse association between dietary copper intake and the odds of COPD for intakes < 1.5 mg/day but no significant association for intakes ≥ 1.5 mg/day. Subgroup analysis indicated an interaction effect with age.
An L-shaped inverse association was observed between dietary copper intake and COPD in US adults, at a threshold of approximately 1.5 mg/day, with an observed age interaction.
铜在人体生理功能中起着至关重要的作用。然而，关于饮食中铜摄入量与慢性阻塞性肺疾病（COPD）之间关联的流行病学证据有限。
本研究旨在评估美国成年人饮食中铜摄入量与COPD之间的关联。
这项横断面研究使用了1999年至2018年美国国家健康与营养检查调查（NHANES）的数据。
参与者/背景：根据纳入标准，本研究纳入了总共39644名20岁及以上成年人的数据，其中3159人已被医疗保健提供者诊断为COPD。
通过24小时饮食回顾获取饮食数据，COPD诊断信息来自标准化的医疗状况问卷。
进行多变量逻辑回归分析以探讨饮食中铜摄入量与COPD之间的关联。为了评估剂量反应关系，采用了三段限制立方样条分析。用两段逻辑回归模型确定潜在阈值。进行亚组分析以评估异质性并探索潜在的相互作用。
与饮食中铜摄入量处于最低三分位数（T1，<0.89毫克/天）的个体相比，处于最高三分位数（T3，>1.35毫克/天）的个体患COPD的调整优势比（OR）为0.79（95%置信区间[CI]，0.68 - 0.92，P = 0.002）。饮食中铜摄入量与COPD之间的关系呈非线性L形曲线（P < 0.001）。阈值分析发现，饮食中铜摄入量<1.5毫克/天时，与COPD患病几率呈统计学显著的负相关，但摄入量≥1.5毫克/天时无显著关联。亚组分析表明存在年龄交互作用。
在美国成年人中，观察到饮食中铜摄入量与COPD之间呈L形负相关，阈值约为1.5毫克/天，且存在年龄交互作用。
