基于微信的EPIC培训对新诊断乳腺癌女性健康相关生活质量、归因及生活态度的影响：一项临床随机对照试验
Effects of WeChat-based EPIC training on health-related quality of life, attribution and life attitude in women newly diagnosed with breast cancer: a clinical randomized controlled trial.
作者信息
Zhou Kaina, Wang Xiao, Wang Yan, Liu Ailan
机构信息
School of Nursing, Xi'an Jiaotong University Health Science Center, No. 76 Yanta West Road, Xi'an, 710061, Shaanxi, China.
Shaanxi Provincial Tumor Hospital, No. 309 Yanta West Road, Xi'an, 710065, Shaanxi, China.
出版信息
Qual Life Res. 2025 Mar 31. doi: 10.1007/s11136-025-03959-2.
PURPOSE
When confronted with healthy functional impairments, the attribution of disease-induced distress plays a key role in the prognosis of health outcomes. This study examined the effects of an attribution-related intervention, namely WeChat-based EPIC (enter, practice, intensify, consolidate) training, on health-related quality of life (HRQoL), attribution, and life attitude in women newly diagnosed with breast cancer.
METHODS
Eligible patients were recruited using convenience sampling and randomly assigned to the intervention or control group via stratified block randomization. The former received WeChat-based EPIC training plus routine nursing care for 6 months. The latter received only routine nursing care. HRQoL (primary indicator), attribution and life attitude (secondary indicators) were measured using the Functional Assessment of Cancer Therapy-Breast version 4.0 (FACT-Bv4.0), Attributional Style Questionnaire (ASQ) and Life Attitude Self-rating Questionnaire for Breast Cancer (LASQ-BC), respectively. A linear mixed model was used to examine the score fluctuations at the 1-, 3-, and 6-month intervals relative to the baseline.
RESULTS
After 6 months, the intervention group (n = 84) showed statistically significant higher total scores in the FACT-Bv4.0 [mean difference: - 15.01; 95% confidence interval: - 17.96, - 12.07; p < 0.001], ASQ [- 4.16 (- 4.45, - 3.86); p < 0.001], and LASQ-BC [- 6.77 (- 8.27, - 5.27); p < 0.001] than that of the control group (n = 82). The total scores of the three indicators also showed significant group, time, and group-by-time interaction effects (p < 0.001).
CONCLUSION
The WeChat-based EPIC training was an effective intervention for improving HRQoL and psychological health in women newly diagnosed with breast cancer.
TRIAL REGISTRATION
Chinese Clinical Trial Registry www.chictr.org.cn , prospectively registered on 11 April 2020, ChiCTR2000031827.
目的
面对健康功能受损时，疾病所致痛苦的归因在健康结局的预后中起关键作用。本研究探讨了一种与归因相关的干预措施，即基于微信的EPIC（进入、实践、强化、巩固）训练，对新诊断乳腺癌女性的健康相关生活质量（HRQoL）、归因和生活态度的影响。
方法
采用便利抽样法招募符合条件的患者，并通过分层整群随机化将其随机分为干预组或对照组。前者接受基于微信的EPIC训练加常规护理6个月。后者仅接受常规护理。分别使用癌症治疗功能评价量表-乳腺癌4.0版（FACT-Bv4.0）、归因方式问卷（ASQ）和乳腺癌生活态度自评问卷（LASQ-BC）测量HRQoL（主要指标）、归因和生活态度（次要指标）。采用线性混合模型检查相对于基线在1、3和6个月时的分数波动。
结果
6个月后，干预组（n = 84）在FACT-Bv4.0 [平均差异：-15.01；95%置信区间：-17.96，-12.07；p < 0.001]、ASQ [-4.16（-4.45，-3.86）；p < 0.001]和LASQ-BC [-6.77（-8.27，-5.27）；p < 0.001]上的总分在统计学上显著高于对照组（n = 82）。这三个指标的总分也显示出显著的组、时间和组×时间交互效应（p < 0.001）。
结论
基于微信的EPIC训练是改善新诊断乳腺癌女性HRQoL和心理健康的有效干预措施。
试验注册
中国临床试验注册中心www.chictr.org.cn，于2020年4月11日前瞻性注册，注册号为ChiCTR2000031827。
Zotero 插件