血细胞比容与常见人类癌症风险之间的相关性：1999 - 2020年观察性调查及孟德尔随机化分析结果

Correlation between hematocrit and the risk of common human cancers: results of a 1999-2020 observational survey and Mendelian randomization analysis.

作者信息

Li Guo-Sheng, Huang Tao, Li Jing-Xiao, Liu Jun, Gao Xiang, Yan Guan-Qiang, Yang Nuo, Zhou Hua-Fu

机构信息

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, P. R. China.

Department of Cardiothoracic Vascular Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P. R. China.

出版信息

Expert Rev Hematol. 2025 Apr;18(4):333-344. doi: 10.1080/17474086.2025.2486381. Epub 2025 Apr 3.

DOI:10.1080/17474086.2025.2486381

PMID:40165040

Abstract

BACKGROUND

Previous studies have underscored the significance of hematocrit (HCT) in different tumors. However, further research is needed to explore its causal relationship with various tumors.

RESEARCH DESIGN AND METHODS

A retrospective analysis and a Mendelian randomization analysis were conducted on a sample of 3,580,275 samples to investigate the causal relationships between high HCT levels and the risks of developing the 15 prevalent malignant tumors. Additionally, using an in-house cohort, Kaplan-Meier curves were utilized to examine the relationship between HCT levels and the prognosis of patients with prostate cancer (PCa).

RESULTS

An elevated HCT level was identified as a protective factor against six types of cancers, including PCa (odds ratio [OR] < 1.000, < 0.05), and a risk factor for cervical cancer, melanoma, and non-melanoma skin cancer (OR > 1.000, < 0.05). A potential causal association was found between high HCT levels and decreased risks of developing PCa (OR = 0.887, < 0.05) and breast cancer (OR = 0.893, < 0.05). HCT was identified as a protective factor against PCa ( < 0.05).

CONCLUSIONS

This study identified significant associations between HCT and nine tumors. HCT levels may serve as a protective factor against PCa.

摘要

背景

既往研究强调了血细胞比容（HCT）在不同肿瘤中的重要性。然而，需要进一步研究以探索其与各种肿瘤之间的因果关系。

研究设计与方法

对3580275个样本进行回顾性分析和孟德尔随机化分析，以研究高HCT水平与15种常见恶性肿瘤发生风险之间的因果关系。此外，利用一个内部队列，采用Kaplan-Meier曲线来检验HCT水平与前列腺癌（PCa）患者预后之间的关系。

结果

HCT水平升高被确定为包括PCa在内的六种癌症的保护因素（优势比[OR]<1.000，<0.05），以及宫颈癌、黑色素瘤和非黑色素瘤皮肤癌的危险因素（OR>1.000，<0.05）。发现高HCT水平与PCa发生风险降低（OR=0.887，<0.05）和乳腺癌发生风险降低（OR=0.893，<0.05）之间存在潜在因果关联。HCT被确定为PCa的保护因素（<0.05）。