Xie Tao, Dong Zhiwei, Wu Chunlin, Ding Qian, Zhan Wenhao, Fu Shumei, Zhang Bihang, Tian Ning
Department of Preventive Treatment for Diseases, Affiliated Guangdong Hospital of Integrated Chinese and Western Medicine of Guangzhou University of Chinese Medicine, Foshan, China.
Department of Standardized Training for Residents, Affiliated Guangzhou Hospital of Integrated Chinese and Western Medicine of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Oncol. 2025 Mar 17;15:1522368. doi: 10.3389/fonc.2025.1522368. eCollection 2025.
The controlling nutritional status (CONUT) score is associated with cancer prognosis. However, a consensus on its prognostic value in patients with non-small cell lung cancer(NSCLC) is lacking. The present study aims to investigate the relationship between the CONUT score and prognostic and clinicopathological features of NSCLC.
The PubMed, Embase, Web of Science and Cochrane Library were searched up to July 2024. Two researchers used the Newcastle Ottawa Scale (NOS) score to evaluate the quality of the included studies and extracted data. The primary and secondary outcomes were overall survival (OS) and disease-free survival (DFS), and the hazard ratio (HR) and 95% confidence interval (CI) were pooled for meta-analysis. The pooled odds ratio (OR) and 95% CI were used to estimate the correlation between the CONUT score and clinical characteristics. Subgroup analysis and sensitivity analysis were performed during the pooled analysis.Funnel plots as well as Begg's and Egger's tests were used to assess publication bias.
Fifteen high-quality studies with 4973 patients were included. The results indicated that a high CONUT score was associated with poor OS (HR = 1.84, 95%CI: 1.55-2.18; P < 0.0001) and DFS (HR=2.40, 95%CI: 1.73-3.34; P < 0.0001).In addition, a high CONUT score was significantly related to male, advanced age, high CEA, and later TNM stage.
The results of our meta-analysis suggest that a high CONUT score predicts a poor prognosis of NSCLC patients. In clinical practice, the CONUT score could act as an valuable tool to predict clinical outcomes in patients with NSCLC.
https://inplasy.com, identifier INPLASY202408280100.
控制营养状况（CONUT）评分与癌症预后相关。然而，对于其在非小细胞肺癌（NSCLC）患者中的预后价值尚未达成共识。本研究旨在探讨CONUT评分与NSCLC患者预后及临床病理特征之间的关系。
检索截至2024年7月的PubMed、Embase、Web of Science和Cochrane图书馆。两名研究人员使用纽卡斯尔渥太华量表（NOS）评分评估纳入研究的质量并提取数据。主要和次要结局为总生存期（OS）和无病生存期（DFS），并汇总风险比（HR）和95%置信区间（CI）进行荟萃分析。汇总优势比（OR）和95%CI用于估计CONUT评分与临床特征之间的相关性。在汇总分析期间进行亚组分析和敏感性分析。采用漏斗图以及Begg检验和Egger检验评估发表偏倚。
纳入了15项高质量研究，共4973例患者。结果表明，高CONUT评分与较差的OS（HR = 1.84，95%CI：1.55 - 2.18；P < 0.0001）和DFS（HR = 2.40，95%CI：1.73 - 3.34；P < 0.0001）相关。此外，高CONUT评分与男性、高龄、高癌胚抗原（CEA）和较晚的TNM分期显著相关。
我们的荟萃分析结果表明，高CONUT评分预示NSCLC患者预后不良。在临床实践中，CONUT评分可作为预测NSCLC患者临床结局的有价值工具。
