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原发性前列腺伯基特淋巴瘤合并噬血细胞性淋巴组织细胞增生症:一例报告及文献复习

Primary prostatic Burkitt's lymphoma complicated with hemophagocytic lymphohistiocytosis: a case report and literature review.

作者信息

Guo Xiong, Ai Wei, Zhang Zhi, Liu Zonglai, Fu Haibo, Gao Pan, Liu Fajun

机构信息

Department of Urology, The Second People's Hospital of China Three Gorges University, The Second People's Hospital of Yichang, Hubei, China.

出版信息

Front Oncol. 2025 Mar 17;15:1553415. doi: 10.3389/fonc.2025.1553415. eCollection 2025.

DOI:10.3389/fonc.2025.1553415
PMID:40165892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11955490/
Abstract

This article reports a very rare case of primary prostatic Burkitt's lymphoma. After transurethral resection of the prostate, the patient developed hemophagocytic lymphohistiocytosis, which rapidly progressed, leading to the patient's death. Unfortunately, a definitive diagnosis was made only in the advanced stages of the disease, contributing to a delay in diagnosis and worsening of the patient's condition. This report aims to improve the understanding of this disease and aid in its early recognition.

摘要

本文报道了一例极为罕见的原发性前列腺伯基特淋巴瘤病例。经尿道前列腺切除术后,患者发生噬血细胞性淋巴组织细胞增生症,病情迅速进展,导致患者死亡。遗憾的是,直到疾病晚期才做出明确诊断,这导致了诊断延误和患者病情恶化。本报告旨在增进对该疾病的了解并有助于早期识别。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/f9fab443b745/fonc-15-1553415-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/8836fe1b56b1/fonc-15-1553415-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/98ca75feeb62/fonc-15-1553415-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/59a5a1236d9a/fonc-15-1553415-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/f9fab443b745/fonc-15-1553415-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/8836fe1b56b1/fonc-15-1553415-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/98ca75feeb62/fonc-15-1553415-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/59a5a1236d9a/fonc-15-1553415-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/007f/11955490/f9fab443b745/fonc-15-1553415-g004.jpg

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本文引用的文献

1
Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria.继发性噬血细胞性淋巴组织细胞增生症诊断标准的多中心验证
J Intern Med. 2025 Mar;297(3):312-327. doi: 10.1111/joim.20065. Epub 2025 Jan 27.
2
Malignancy-associated HLH: mechanisms, diagnosis, and treatment of a severe hyperinflammatory syndrome.恶性肿瘤相关噬血细胞性淋巴组织细胞增生症:一种严重高炎症综合征的机制、诊断与治疗
Leuk Lymphoma. 2025 Apr;66(4):628-636. doi: 10.1080/10428194.2024.2436037. Epub 2024 Dec 10.
3
Hemophagocytic lymphohistiocytosis: current treatment advances, emerging targeted therapy and underlying mechanisms.
噬血细胞性淋巴组织细胞增生症:当前的治疗进展、新兴的靶向治疗和潜在机制。
J Hematol Oncol. 2024 Nov 7;17(1):106. doi: 10.1186/s13045-024-01621-x.
4
Lymphoma-associated hemophagocytic syndrome: a retrospective, single-center study of 86 patients.淋巴瘤相关噬血细胞综合征:86 例回顾性单中心研究。
Ann Hematol. 2024 Sep;103(9):3649-3656. doi: 10.1007/s00277-024-05900-y. Epub 2024 Jul 30.
5
Primary prostate Burkitt's lymphoma resected with holmium laser enucleation of the prostate: A rare case report.经钬激光前列腺剜除术切除的原发性前列腺伯基特淋巴瘤:一例罕见病例报告。
World J Clin Cases. 2023 Jun 26;11(18):4406-4411. doi: 10.12998/wjcc.v11.i18.4406.
6
Diagnosis and Management of Adult Malignancy-Associated Hemophagocytic Lymphohistiocytosis.成人恶性肿瘤相关性噬血细胞性淋巴组织细胞增生症的诊断与管理
Cancers (Basel). 2023 Mar 18;15(6):1839. doi: 10.3390/cancers15061839.
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Burkitt lymphoma.伯基特淋巴瘤。
Nat Rev Dis Primers. 2022 Dec 15;8(1):78. doi: 10.1038/s41572-022-00404-3.
8
Burkitt lymphoma after solid-organ transplant: Treatment and outcomes in the paediatric PTLD collaborative.实体器官移植后伯基特淋巴瘤:儿科 PTLD 协作中的治疗和结局。
Br J Haematol. 2023 Feb;200(3):297-305. doi: 10.1111/bjh.18498. Epub 2022 Dec 1.
9
Anakinra for the Treatment of Hemophagocytic Lymphohistiocytosis: 21 Cases.阿那白滞素治疗噬血细胞性淋巴组织细胞增生症:21例报告
J Clin Med. 2022 Sep 30;11(19):5799. doi: 10.3390/jcm11195799.
10
The emerging role of anti-PD-1 antibody-based regimens in the treatment of extranodal NK/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis.基于抗PD-1抗体的治疗方案在结外NK/T细胞淋巴瘤相关噬血细胞性淋巴组织细胞增生症治疗中的新兴作用。
J Cancer Res Clin Oncol. 2023 May;149(5):2017-2027. doi: 10.1007/s00432-022-04147-2. Epub 2022 Jul 9.