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FeO纳米颗粒、药物和染料的不同共轭物：用于双峰成像的光学和磁性特性。

Different conjugates of FeO nanoparticles, drug, and dye: optical and magnetic properties for bimodal imaging.

作者信息

Le Thi Thu Huong, Phan Ke Son, Doan Bich Thuy, Mai Thi Thu Trang, Bui Ha Bao Hung, Pham Hong Nam, Ung Thi Dieu Thuy, Wang Yiqian, Tran Ngoc Quyen, Dang Le Hang, Ha Phuong Thu

机构信息

Faculty of Natural Resources and Environment, Vietnam National University of Agriculture Hanoi Vietnam.

Institute of Materials Science, Vietnam Academy of Science and Technology Hanoi Vietnam

出版信息

RSC Adv. 2025 Mar 31;15(13):9644-9656. doi: 10.1039/d4ra07910h. eCollection 2025 Mar 28.

DOI:10.1039/d4ra07910h
PMID:40165912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11955827/
Abstract

Bioimaging is very important in medicine, especially in cancer diagnosis and treatment. In this study, we determined the impact of different components on the optical and magnetic properties of various conjugates. The three components, , FeO nanoparticles (NPs), drug (doxorubicin - Dox), and dye (Cyanine 5.5 - Cy 5.5), were incorporated to form the four conjugates of A1 (FeO-Cy 5.5), A2 (FeO-Dox), A3 (FeO-Cy 5.5-Dox), and A4 (Cy 5.5-Dox). The conjugates were characterized by DLS, UV-Vis spectra, fluorescence spectra, VSM, XRD, and TEM methods. After that, near-infrared (NIR) fluorescence imaging and magnetic resonance imaging (MRI) experiments were carried out to determine the conjugate suitable for bimodal imaging. The results show that A3 exhibits the highest quantum yield and radiance ratio and also has the highest ratio of / . The MRI and NIR fluorescent imaging results of CT26-bearing mice injected with A3 conjugates prove that the conjugate has potential in bimodal cancer imaging applications.

摘要

生物成像在医学中非常重要，尤其是在癌症诊断和治疗方面。在本研究中，我们确定了不同组分对各种共轭物的光学和磁性的影响。将三种组分，即FeO纳米颗粒（NPs）、药物（阿霉素 - Dox）和染料（花菁5.5 - Cy 5.5）结合起来，形成了四种共轭物A1（FeO - Cy 5.5）、A2（FeO - Dox）、A3（FeO - Cy 5.5 - Dox）和A4（Cy 5.5 - Dox）。通过动态光散射（DLS）、紫外 - 可见光谱、荧光光谱、振动样品磁强计（VSM）、X射线衍射（XRD）和透射电子显微镜（TEM）方法对这些共轭物进行了表征。之后，进行了近红外（NIR）荧光成像和磁共振成像（MRI）实验，以确定适用于双模态成像的共轭物。结果表明，A3表现出最高的量子产率和辐射率，并且/的比率也最高。注射了A3共轭物的荷CT26小鼠的MRI和NIR荧光成像结果证明，该共轭物在双模态癌症成像应用中具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/781c2bc9b1aa/d4ra07910h-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/ae989478d8f3/d4ra07910h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/2736c9809097/d4ra07910h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/7b1859b9f0f9/d4ra07910h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/16bea79f6ad8/d4ra07910h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/6bbf180a50c0/d4ra07910h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/53a377202b3e/d4ra07910h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/5721c559039e/d4ra07910h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/ac284b6f0b0b/d4ra07910h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/5bae66886877/d4ra07910h-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/781c2bc9b1aa/d4ra07910h-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/ae989478d8f3/d4ra07910h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/2736c9809097/d4ra07910h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/7b1859b9f0f9/d4ra07910h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/16bea79f6ad8/d4ra07910h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/6bbf180a50c0/d4ra07910h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/53a377202b3e/d4ra07910h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/5721c559039e/d4ra07910h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/ac284b6f0b0b/d4ra07910h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/5bae66886877/d4ra07910h-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a99e/11955827/781c2bc9b1aa/d4ra07910h-f10.jpg

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ChemMedChem. 2025-3-3

[2]
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[3]
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2024

[4]
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J Control Release. 2024-4

[5]
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[6]
Recent advances in optical imaging through deep tissue: imaging probes and techniques.

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[7]
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[8]
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Br J Radiol. 2022-7-1

[9]
Effect of Doxorubicin on the Near-Infrared Optical Properties of Indocyanine Green.

ACS Omega. 2021-12-10

[10]
The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application.

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