Jaiswal Saumya, Dutta Surjendu Bikash, Nayak Debasis, Gupta Sharad
Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Indore 453552 Madhya Pradesh, India.
Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal 462066 Madhya Pradesh, India.
ACS Omega. 2021 Dec 10;6(50):34842-34849. doi: 10.1021/acsomega.1c05500. eCollection 2021 Dec 21.
In recent years, chemo-photothermal therapy (chemo-PTT) has been extensively studied for the upgradation of cancer treatment. The combined therapeutic approach reduces the overall cytotoxicity and enhances the therapeutic effect against the cancerous cells. In chemo-PTT, Indocyanine green (ICG) dye, a near-infrared chromophore, is used for PTT in combination with doxorubicin (DOX), a chemotherapeutic drug. ICG and DOX work very efficiently in synergy against cancer. However, the effect of DOX on the optical properties of ICG has not been studied yet. Here, for the first time, we report the effect of DOX on the optical properties of ICG in detail. DOX interacts with ICG and induces the aggregation of ICG even at a low concentration. The coincubation of both the molecules causes H and J aggregations in ICG. However, the J aggregation becomes more prominent with an increasing DOX concentration. These findings suggest that the optical properties of ICG change upon incubation with the DOX, which might affect the efficacy of PTT.
近年来，化学光热疗法（chemo-PTT）已被广泛研究用于癌症治疗的升级。这种联合治疗方法降低了总体细胞毒性，并增强了对癌细胞的治疗效果。在chemo-PTT中，吲哚菁绿（ICG）染料（一种近红外发色团）与化疗药物阿霉素（DOX）联合用于光热疗法。ICG和DOX在协同对抗癌症方面非常有效。然而，DOX对ICG光学性质的影响尚未得到研究。在此，我们首次详细报道了DOX对ICG光学性质的影响。DOX与ICG相互作用，即使在低浓度下也会诱导ICG聚集。两种分子的共孵育导致ICG中出现H聚集和J聚集。然而，随着DOX浓度的增加，J聚集变得更加明显。这些发现表明，ICG与DOX共孵育后其光学性质发生变化，这可能会影响光热疗法的疗效。
