Yamamoto Shinji, Okada Yukinori
Department of Radiological Technology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Tokyo, JPN.
Department of Radiology, Tokyo Medical University Hospital, Tokyo, JPN.
Cureus. 2025 Feb 28;17(2):e79857. doi: 10.7759/cureus.79857. eCollection 2025 Feb.
F-fluorodeoxyglucose (F-FDG) is a radiopharmaceutical that exhibits glucose-like kinetics and is used in positron emission tomography (PET). F-FDG is used for cancer diagnosis in clinical practice. However, F-FDG uptake is also observed in normal organs, such as the brain, liver, and heart, with high glucose consumption. Moreover, F-FDG uptake is also observed in muscles, where its accumulation and radioactivity reflect muscle activity. Dystonia is characterized by excessive muscle movement. Recently, F-FDG and technetium-99m-methoxyisobutyl isocyanide ([99mTc]MIBI) have been used for the diagnosis and botulinum toxin therapy evaluation of dystonia. This review aimed to summarize the utility of F-FDG-PET for the evaluation of muscle activity and diagnosis of muscle diseases such as dystonia, polymyositis, dermatomyositis, and polymyalgia rheumatica.
氟脱氧葡萄糖（F-FDG）是一种具有类似葡萄糖动力学的放射性药物，用于正电子发射断层扫描（PET）。F-FDG在临床实践中用于癌症诊断。然而，在正常器官如大脑、肝脏和心脏中也观察到F-FDG摄取，这些器官葡萄糖消耗较高。此外，在肌肉中也观察到F-FDG摄取，其在肌肉中的积聚和放射性反映了肌肉活动。肌张力障碍的特征是肌肉过度运动。最近，F-FDG和锝-99m-甲氧基异丁基异腈（[99mTc]MIBI）已用于肌张力障碍的诊断和肉毒杆菌毒素治疗评估。本综述旨在总结F-FDG-PET在评估肌肉活动以及诊断肌张力障碍、多发性肌炎、皮肌炎和风湿性多肌痛等肌肉疾病方面的应用。
