• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

溶骨性病变：一个意外的诊断。

Osteolytic Lesions: An Unexpected Diagnosis.

作者信息

Mesquita Pedro, Ferreira da Silva Diogo, Mateus Sofia, Costa Teresa Maria, Ferrão Vale Luís

机构信息

Internal Medicine, Unidade Local de Saúde de São José, Hospital de Santo António dos Capuchos, Lisboa, PRT.

Surgical Pathology, Unidade Local de Saúde Lisboa Ocidental, Lisboa, PRT.

出版信息

Cureus. 2025 Feb 28;17(2):e79808. doi: 10.7759/cureus.79808. eCollection 2025 Feb.

DOI:10.7759/cureus.79808
PMID:40166524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11955578/
Abstract

This is the case of a patient who went to the emergency department with back pain and constitutional symptoms (weight loss, anorexia, nausea) lasting one month. Blood tests revealed hypercalcemia and new-onset kidney failure that prompted admission for study. Bone X-ray revealed multiple lytic lesions, and myeloma screening was negative. After a bone marrow biopsy guided by ultrasound of one lesion, it was possible to obtain the diagnosis of diffuse large B-cell lymphoma. We present this case for the diagnostic challenge and atypical presentation simulating multiple myeloma with hypercalcemia.

摘要

这是一名因背痛和全身症状（体重减轻、厌食、恶心）持续一个月而前往急诊科就诊的患者。血液检查显示高钙血症和新发肾衰竭，促使其入院进行检查。骨骼X线检查发现多个溶骨性病变，骨髓瘤筛查呈阴性。在对一个病变进行超声引导下的骨髓活检后，得以诊断为弥漫性大B细胞淋巴瘤。我们展示此病例是因其诊断具有挑战性且临床表现不典型，类似伴有高钙血症的多发性骨髓瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af90/11955578/50499efd522b/cureus-0017-00000079808-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af90/11955578/2b3343b00b3d/cureus-0017-00000079808-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af90/11955578/9baf91f646fd/cureus-0017-00000079808-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af90/11955578/50499efd522b/cureus-0017-00000079808-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af90/11955578/2b3343b00b3d/cureus-0017-00000079808-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af90/11955578/9baf91f646fd/cureus-0017-00000079808-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af90/11955578/50499efd522b/cureus-0017-00000079808-i03.jpg

相似文献

1
Osteolytic Lesions: An Unexpected Diagnosis.溶骨性病变：一个意外的诊断。
Cureus. 2025 Feb 28;17(2):e79808. doi: 10.7759/cureus.79808. eCollection 2025 Feb.
2
Primary Bone Lymphoma Masquerading as Multiple Myeloma: Challenges in the Diagnostic Workup of Severe Hypercalcemia.伪装成多发性骨髓瘤的原发性骨淋巴瘤：重度高钙血症诊断检查中的挑战。
Cureus. 2024 Jan 8;16(1):e51856. doi: 10.7759/cureus.51856. eCollection 2024 Jan.
3
Multiple bone lesions and hypercalcemia presented in diffuse large B cell lymphoma: mimicking multiple myeloma?弥漫性大 B 细胞淋巴瘤中出现多处骨病变和高钙血症：是否类似于多发性骨髓瘤？
Int J Hematol. 2010 May;91(4):716-22. doi: 10.1007/s12185-010-0562-4. Epub 2010 Apr 9.
4
[Hypercalcemia and osteolytic lesions associated with pre-B-cell primary lymphoma of the bone marrow. A case report].[与骨髓前B细胞原发性淋巴瘤相关的高钙血症和溶骨性病变。病例报告]
Rev Invest Clin. 1990 Jul-Sep;42(3):226-30.
5
Multiple myeloma presenting as acute pancreatitis.以急性胰腺炎为表现的多发性骨髓瘤。
Am J Emerg Med. 2017 Sep;35(9):1385.e1-1385.e2. doi: 10.1016/j.ajem.2017.06.009. Epub 2017 Jun 6.
6
Osteolytic bone lesions, severe hypercalcemia without circulating blasts: unusual presentation of childhood acute lymphoblastic leukemia.溶骨性骨病变，无循环原始细胞的严重高钙血症：儿童急性淋巴细胞白血病的不寻常表现。
Pan Afr Med J. 2017 Apr 28;26:244. doi: 10.11604/pamj.2017.26.244.10506. eCollection 2017.
7
Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression.伴有局灶性骨髓受累及异常细胞角蛋白表达的非分泌型多发性骨髓瘤
Acta Med Port. 2021 Nov 2;34(11):778-781. doi: 10.20344/amp.13235. Epub 2021 Sep 8.
8
Hypercalcaemia, Renal Dysfunction, Anaemia, Bone Disease (CRAB Criteria): A Case of Lymphoma.高钙血症、肾功能不全、贫血、骨病（CRAB标准）：一例淋巴瘤病例
Eur J Case Rep Intern Med. 2020 Dec 21;7(12):002140. doi: 10.12890/2020_002140. eCollection 2020.
9
Bone metastatic carcinoma coexisting with plasma cell myeloma: a case report.骨转移癌合并浆细胞骨髓瘤：病例报告。
J Med Case Rep. 2022 Dec 23;16(1):477. doi: 10.1186/s13256-022-03688-x.
10
B-cell lymphoma mimicking multiple myeloma.
Leuk Lymphoma. 2002 Sep;43(9):1869-73. doi: 10.1080/1042819021000006556.

本文引用的文献

1
Primary and secondary bone lymphomas.原发性和继发性骨淋巴瘤。
Cancer Treat Rev. 2015 Mar;41(3):235-46. doi: 10.1016/j.ctrv.2015.02.001. Epub 2015 Feb 7.
2
Young males with primary lymphoma of bone presenting with musculoskeletal pain are prone to be misdiagnosed as ankylosing spondylitis: a case report.年轻男性因原发性骨淋巴瘤伴骨骼肌肉疼痛就诊，易误诊为强直性脊柱炎：病例报告。
Rheumatol Int. 2012 Jan;32(1):263-4. doi: 10.1007/s00296-010-1776-8. Epub 2011 Jan 15.
3
A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency.
131例原发性骨淋巴瘤患者的临床病理回顾性研究：一项基于人群的对不列颠哥伦比亚癌症机构连续治疗队列的研究
Ann Oncol. 2007 Jan;18(1):129-135. doi: 10.1093/annonc/mdl329. Epub 2006 Oct 3.
4
Primary reticulum-cell sarcoma of bone; summary of 37 cases.原发性骨网状细胞肉瘤；37例总结
Radiology. 1950 Nov;55(5):641-58. doi: 10.1148/55.5.641.
5
Oncologic outcomes of primary lymphoma of bone in adults.成人原发性骨淋巴瘤的肿瘤学结局
Clin Orthop Relat Res. 2003 Oct(415):90-7. doi: 10.1097/01.blo.0000093901.12372.ad.
6
Primary non-Hodgkin's lymphoma of bone: a clinicopathological investigation of 60 cases.骨原发性非霍奇金淋巴瘤：60例临床病理研究
Leukemia. 1999 Dec;13(12):2094-8. doi: 10.1038/sj.leu.2401582.