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在减轻抗生素诱导的小鼠和人类肠道菌群失调的后果方面，植物性肠内营养优于人工营养。

Plant based enteral nutrition outperforms artificial nutrition in mitigating consequences of antibiotic-induced dysbiosis in mice and humans.

作者信息

Chatrizeh Mona, Tian Jianmin, Rogers Matthew, Feturi Firuz, Wu Guojun, Firek Brian, Nikonov Roman, Cass Lauren, Sheppeck Alexandra, Ramos-Jiménez Rafael G, Ohja Lavnish, Caroll Ali, Henkel Mathew, Azar Justin, Aneja Rajesh K, Campfield Brian, Simon Dennis, Morowitz Michael J

机构信息

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

出版信息

medRxiv. 2025 Mar 20:2025.03.19.25323813. doi: 10.1101/2025.03.19.25323813.

DOI:10.1101/2025.03.19.25323813
PMID:40166543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11957089/
Abstract

Malnutrition, gut inflammation, and antibiotic induced dysbiosis (AID) are omnipresent risk factors for poor clinical outcomes among critically ill patients. We previously showed that commercially available plant-based enteral nutrition (PBEN) preserves a commensal microbiome when compared to commonly used forms of commercially available artificial enteral nutrition (AEN). This study reveals that PBEN is superior to artificial enteral nutrition (AEN) in recovering from antibiotic-induced dysbiosis (AID) in mice and humans. PBEN effectively mitigates anemia, leukopenia, restores naïve lymphocyte populations, and reduces bone marrow myeloid cell expansion. Animals randomized to PBEN also fared better in response to infectious challenges after antibiotics. A pilot clinical study validated these findings, showing increased gut commensals, reduced pathogens, and improved leukocyte balance in critically ill patients receiving PBEN compared to AEN. These results suggest PBEN offers a practical dietary approach to mitigate antibiotic-associated complications and improve clinical outcomes among hospitalized patients requiring supplemental nutrition.

摘要

营养不良、肠道炎症和抗生素诱导的菌群失调（AID）是重症患者临床预后不良的普遍危险因素。我们之前表明，与常用的市售人工肠内营养（AEN）形式相比，市售植物性肠内营养（PBEN）可维持共生微生物群。这项研究表明，在小鼠和人类中，PBEN在从抗生素诱导的菌群失调（AID）中恢复方面优于人工肠内营养（AEN）。PBEN有效减轻贫血、白细胞减少，恢复初始淋巴细胞群体，并减少骨髓髓样细胞扩增。随机接受PBEN的动物在抗生素治疗后的感染挑战中也表现得更好。一项初步临床研究验证了这些发现，表明与接受AEN的重症患者相比，接受PBEN的患者肠道共生菌增加、病原体减少且白细胞平衡改善。这些结果表明，PBEN提供了一种实用的饮食方法，可减轻抗生素相关并发症，并改善需要补充营养的住院患者的临床预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/a2828a58e596/nihpp-2025.03.19.25323813v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/0832159b8cc2/nihpp-2025.03.19.25323813v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/ddf4941bdef0/nihpp-2025.03.19.25323813v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/cce64a449841/nihpp-2025.03.19.25323813v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/9e718c5c4441/nihpp-2025.03.19.25323813v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/ddef398732f1/nihpp-2025.03.19.25323813v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/3c83da476074/nihpp-2025.03.19.25323813v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/a2828a58e596/nihpp-2025.03.19.25323813v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/0832159b8cc2/nihpp-2025.03.19.25323813v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/ddf4941bdef0/nihpp-2025.03.19.25323813v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/cce64a449841/nihpp-2025.03.19.25323813v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/9e718c5c4441/nihpp-2025.03.19.25323813v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/ddef398732f1/nihpp-2025.03.19.25323813v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/3c83da476074/nihpp-2025.03.19.25323813v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eb3/11957089/a2828a58e596/nihpp-2025.03.19.25323813v1-f0007.jpg

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