新生儿庆大霉素谷浓度升高的相关因素：剂量与临床参数的回顾性分析
Factors associated with elevated gentamicin trough levels in neonates: a retrospective analysis of dosing and clinical parameters.
作者信息
Trah Julian, Deindl Philipp, Luister Alexandra, Langebrake Claudia, Singer Dominique, Ebenebe Chinedu Ulrich
机构信息
Department of Neonatology and Pediatric Intensive Care Medicine, University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department for Pediatric Rehabilitation, VAMED Rehabilitation Hospital, Geesthacht, Germany.
出版信息
Front Pediatr. 2025 Mar 17;13:1510838. doi: 10.3389/fped.2025.1510838. eCollection 2025.
OBJECTIVE
Investigate determinants of elevated gentamicin trough levels in neonates.
METHODS
This single-center retrospective analysis used a multivariate linear regression model to explore the relationship between gentamicin trough concentrations and factors such as creatinine levels, dosage, day of life, sex, CRP levels, and dosing interval in neonates.
RESULTS
In 215 neonates, including 68 (31.6%) premature neonates with a postmenstrual age of ≤35 weeks, shorter dosing intervals, higher creatinine levels, and increased dosage were linked to higher gentamicin trough levels. Elevated CRP levels corresponded with lower trough levels.
CONCLUSION
This study highlights the critical role of dosing frequency, kidney function, and inflammatory status in influencing gentamicin trough levels in neonates. However, all gentamicin trough levels were within the 2 µg/ml threshold.
目的
研究新生儿庆大霉素谷浓度升高的决定因素。
方法
本单中心回顾性分析采用多元线性回归模型，探讨新生儿庆大霉素谷浓度与肌酐水平、剂量、日龄、性别、CRP水平及给药间隔等因素之间的关系。
结果
在215例新生儿中，包括68例（31.6%）孕龄≤35周的早产儿，给药间隔较短、肌酐水平较高及剂量增加与庆大霉素谷浓度较高有关。CRP水平升高与谷浓度较低相对应。
结论
本研究强调了给药频率、肾功能和炎症状态在影响新生儿庆大霉素谷浓度方面的关键作用。然而，所有庆大霉素谷浓度均在2μg/ml阈值范围内。
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