Luo Wenbo, Tang Pingping, Lv Yan, Song Yijun, Hu Huiying, Gao Jinsong, Liu Juntao
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Obstetric and Gynecologic Diseases, Beijing, China.
AJP Rep. 2025 Mar 31;15(1):e36-e42. doi: 10.1055/a-2555-1742. eCollection 2025 Jan.
To evaluate the association of PIGF and sFlt-1 with low birth weight and/or small-for-gestational age neonates in pregnancy with or without preeclampsia.
Singleton pregnancies with sFlt-1/PlGF tested were included and set into four groups for case-control analysis. Distribution of sFlt-1/PlGF, sFlt-1, PlGF, and PGF% were evaluated, Kruskal-Wallis test and Mann-Whitney U test were adopted for significance analysis.
Maternal sFlt-1/PlGF, PlGF, PlGF%, and sFlt-1 were statistically associated with low birth weight and/or small-for-gestational age in pregnancy complicated or uncomplicated with preeclampsia. A significant difference was shown on sFlt-1/PIGF ( = 0.0082), PIGF% ( = 0.0326), PIGF ( = 0.0128), and sFlt-1 ( = 0.0469) in pregnancy with small-for-gestational age and/or low birth weight neonates. A significantly higher median of sFlt-1/PlGF (448 vs. 61.6, < 0.0001) and sFlt-1 (15499 vs. 3226, < 0.0001), a significantly lower median of PlGF (33.92 vs. 115.2, < 0.0001) and PlGF% (-76.63 vs. -20.31, < 0.0001) were demonstrated, respectively, when preeclampsia with small-for-gestational age and/or low birth weight neonates was compared with preeclampsia with normal birth weight neonates. No significant difference was demonstrated between low birth weight and small-for-gestational age on sFlt-1/PlGF, PlGF, PlGF%, and sFlt-1.
sFlt-1/PlGF seems to be a promising biomarker in predicting low birth weight and/or small-for-gestational age neonates in pregnancy with or without preeclampsia.
评估胎盘生长因子（PIGF）和可溶性血管内皮生长因子受体-1（sFlt-1）与患有或未患有子痫前期的妊娠中低出生体重和/或小于胎龄新生儿的相关性。
纳入进行了sFlt-1/胎盘生长因子（PlGF）检测的单胎妊娠，并分为四组进行病例对照分析。评估sFlt-1/PlGF、sFlt-1、PlGF和PGF%的分布情况，采用Kruskal-Wallis检验和Mann-Whitney U检验进行显著性分析。
在患有或未患有子痫前期的妊娠中，母体sFlt-1/PlGF、PlGF、PlGF%和sFlt-1与低出生体重和/或小于胎龄具有统计学相关性。在小于胎龄和/或低出生体重新生儿的妊娠中，sFlt-1/PIGF（P = 0.0082）、PIGF%（P = 0.0326）、PIGF（P = 0.0128）和sFlt-1（P = 0.0469）显示出显著差异。与出生体重正常的子痫前期新生儿相比，患有小于胎龄和/或低出生体重新生儿的子痫前期患者中，sFlt-1/PlGF（448对61.6，P < 0.0001）和sFlt-1（15499对3226，P < 0.0001）的中位数显著更高，PlGF（33.92对115.2，P < 0.0001）和PlGF%（-76.63对-20.31，P < 0.0001）的中位数显著更低。在低出生体重和小于胎龄之间，sFlt-1/PlGF、PlGF、PlGF%和sFlt-1未显示出显著差异。
sFlt-1/PlGF似乎是预测患有或未患有子痫前期妊娠中低出生体重和/或小于胎龄新生儿的一个有前景的生物标志物。
