Zhang YanKun, Zhang Xuan, Dong Jie, Liu Fang
Department of Dermatology, Venereology and Cosmetology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Mar 27;18:743-753. doi: 10.2147/CCID.S508231. eCollection 2025.
Recent advances in epidemiological and genetic studies have provided some insights regarding the pathophysiology of rosacea, but the majority of its underlying mechanisms are still poorly understood. In particular, more data are needed to fully understand the role of micronutrients in rosacea development. This study aimed to explore the causality of associations between Calcium, Copper, Selenium, Zinc, Iron, Potassium and Magnesium with the risk of rosacea.
This was a two-sample Mendelian Randomization (MR) study that used data from genome-wide association studies (GWAS) on serum levels of selected micronutrients as exposure and rosacea as the outcome. The analysis primarily employed the Inverse Variance Weighted (IVW) method. Additional methods included weighted median, weighted mode, and MR-Egger regression. Sensitivity analysis included MR-Egger, MR-PRESSO, Cochran's Q, and leave-one-out methods. A total of 301 Instrumental Variables were selected for analysis.
The genetic prediction indicated a statistically significant association between serum Calcium levels and higher rosacea risk (Odds Ratio (OR) = 2.27, 95% Confidence Interval (CI): 2.02-2.55, P < 0.001), further confirmed by all supplementary MR methods. Significant association was also found between serum Potassium levels and lower rosacea risk (OR = 0.36, 95% CI: 0.14-0.93, P = 0.0354), further confirmed by the weighted-median method. Sensitivity analyses showed that the results were robust and not driven by any single factor, with low probability of horizontal pleiotropy.
This study found an evidence of a causal association between genetically predicted serum levels of Calcium and Potassium with the risk of rosacea. The roles of these micronutrients should be further studied in rosacea, especially as a link to neurovascular dysregulation and oxidative stress.
流行病学和遗传学研究的最新进展为酒渣鼻的病理生理学提供了一些见解，但其大多数潜在机制仍知之甚少。特别是，需要更多数据来全面了解微量营养素在酒渣鼻发展中的作用。本研究旨在探讨钙、铜、硒、锌、铁、钾和镁与酒渣鼻风险之间关联的因果关系。
这是一项两样本孟德尔随机化（MR）研究，使用全基因组关联研究（GWAS）的数据，将选定微量营养素的血清水平作为暴露因素，酒渣鼻作为结局。分析主要采用逆方差加权（IVW）方法。其他方法包括加权中位数、加权模式和MR-Egger回归。敏感性分析包括MR-Egger、MR-PRESSO、 Cochr an检验的Q值和逐一剔除法。共选择301个工具变量进行分析。
基因预测表明血清钙水平与较高的酒渣鼻风险之间存在统计学显著关联（优势比（OR）=2.27，95%置信区间（CI）：2.02-2.55，P<0.001），所有补充MR方法均进一步证实了这一点。血清钾水平与较低的酒渣鼻风险之间也发现了显著关联（OR = 0.36，95%CI：0.14-0.93，P = 0.0354），加权中位数方法进一步证实了这一点。敏感性分析表明结果稳健，不受任何单一因素驱动，水平多效性概率较低。
本研究发现基因预测的血清钙和钾水平与酒渣鼻风险之间存在因果关联的证据。这些微量营养素在酒渣鼻中的作用应进一步研究，特别是作为与神经血管失调和氧化应激的联系。
