Powderly W G, Cantwell B M, Fennelly J J, Warde P, McCabe M M, Towers R P
Cancer. 1985 Aug 15;56(4):874-5. doi: 10.1002/1097-0142(19850815)56:4<874::aid-cncr2820560428>3.0.co;2-l.
From a series of 138 patients with Hodgkin's disease seen over a 17-year period, 2 developed the nephrotic syndrome. One patient developed hematuria unrelated to cytotoxic chemotherapy or thrombocytopenia. All three patients had evidence of glomerulopathy on histologic examination of renal tissue, but none had the more usually associated minimal-change glomerular histologic features. The patients with nephrotic syndrome had effective clinical regression with systemic chemotherapy. The significance of renal glomerular disease in association with Hodgkin's disease is discussed.
在17年期间诊治的138例霍奇金病患者中，有2例发生了肾病综合征。1例患者出现血尿，与细胞毒性化疗或血小板减少无关。所有3例患者在肾组织的组织学检查中均有肾小球病变的证据，但均无通常与之相关的微小病变肾小球组织学特征。肾病综合征患者经全身化疗后临床症状有效缓解。本文讨论了与霍奇金病相关的肾小球疾病的意义。
