Petrek J A, Sandberg W A, Bean P K
Cancer. 1985 Aug 15;56(4):952-5. doi: 10.1002/1097-0142(19850815)56:4<952::aid-cncr2820560441>3.0.co;2-8.
Fifty patients from a socioeconomically disadvantaged population who were diagnosed when younger than 40 with colorectal cancer between 1968 and 1978 were analyzed. These patients had an increased survival compared with their older counterparts aged 40 years and older who were diagnosed during the same time. The young women had significantly better survival than the young men. Advanced stages, distribution of primary sites, and precancerous conditions were not major factors. The fact that the younger patients' cancers had a higher incidence of extracellular mucin production may have been counterbalanced by their receiving more extensive treatment. At the same time, cultural and social factors related to gender may have more to do with better survival than do factors evaluated in previous studies. In fact, because of the pervasive lack of male/female analysis, it is not known whether the survival difference due to gender found in this report is a universal tendency in young populations.
对1968年至1978年间50名来自社会经济弱势人群且在40岁之前被诊断为结直肠癌的患者进行了分析。与同期被诊断出患有结直肠癌的40岁及以上的老年患者相比，这些年轻患者的生存率有所提高。年轻女性的生存率明显高于年轻男性。晚期阶段、原发部位分布和癌前病变并非主要因素。年轻患者的癌症细胞外粘蛋白产生发生率较高这一事实，可能因其接受了更广泛的治疗而得到了平衡。与此同时，与性别相关的文化和社会因素可能比先前研究中评估的因素对更好的生存率起到了更大的作用。事实上，由于普遍缺乏对男性/女性的分析，尚不清楚本报告中发现的因性别导致的生存差异是否是年轻人群中的普遍趋势。
