Izenour Katie, Salib Fayez, Eckert Jordan, Jesudoss Chelladurai Jeba R J, Starkey Lindsay, Blagburn Byron, Sundermann Christine, Willoughby Janna, Zohdy Sarah
Department of Pathobiology, Auburn University, Auburn, AL, USA.
Faculty of Veterinary Medicine, Cairo University, Giza Governorate, CairoEgypt.
Parasitology. 2025 Apr;152(4):347-365. doi: 10.1017/S003118202500037X.
and are globally distributed mosquito-borne parasitic filarial nematodes. Data on the prevalence of spp. is not aggregated or publicly available at the national level for countries in North Africa and the Middle East. A systematic review and meta-analysis of publications describing cases of and in 21 countries in North Africa and the Middle East was performed following PRISMA guidelines to estimate the prevalence of spp. where national and regional estimates don’t exist. In total, 460 publications were reviewed, and 34 met all inclusion criteria for the meta-analysis model. This analysis found that the combined prevalence of spp. in the included countries was 2.4% (95% CI: 1.6–3.6%; = 81.7%, 95% CI: 78.6–84.3%). Moderator analysis showed a statistically significant difference in the prevalence estimate between diagnostic test methods used. The model detected a high degree of heterogeneity among studies and publication bias. Removal of model identified outliers reduced the estimated prevalence from 2.4% to 1.0%, whereas the trim-and-fill analysis suggested a higher adjusted prevalence (12%). Despite these findings, spp. prevalence is likely dynamic due to seasonal variations in mosquito vector populations and differences in local mosquito control practices. Additional studies from the countries in and surrounding this region are needed to better identify key risk factors for spp. in domestic canids and other species (including humans) to inform prevention and control decisions to limit further transmission.
[虫名1]和[虫名2]是全球分布的蚊媒寄生丝状线虫。在北非和中东国家，关于[虫名1]属物种流行率的数据未在国家层面进行汇总或公开。按照PRISMA指南，对描述北非和中东21个国家[虫名1]和[虫名2]病例的出版物进行了系统评价和荟萃分析，以估计在缺乏国家和区域估计数据的情况下[虫名1]属物种的流行率。总共审查了460篇出版物，其中34篇符合荟萃分析模型的所有纳入标准。该分析发现，纳入国家中[虫名1]属物种的综合流行率为2.4%（95%置信区间：1.6 - 3.6%；I² = 81.7%，95%置信区间：78.6 - 84.3%）。调节因素分析显示，所使用的诊断测试方法之间的流行率估计存在统计学显著差异。该模型检测到研究之间存在高度异质性和发表偏倚。去除模型识别出的异常值后，估计流行率从2.4%降至1.0%，而修剪填充分析表明调整后的流行率更高（12%）。尽管有这些发现，但由于蚊媒种群的季节性变化和当地蚊虫控制措施的差异，[虫名1]属物种的流行率可能是动态的。需要对该地区及其周边国家进行更多研究，以更好地确定家犬和其他物种（包括人类）中[虫名1]属物种的关键风险因素，为预防和控制决策提供信息，以限制进一步传播。
