Nelson D F, Cassady J R, Traggis D, Baez-Giangreco A, Vawter G F, Jaffe N, Filler R M
Cancer. 1977 Jan;39(1):89-97. doi: 10.1002/1097-0142(197701)39:1<89::aid-cncr2820390117>3.0.co;2-i.
Forty children with localized resectable intestinal non-Hodgkin's lymphoma were seen between 1948 and 1974. Survival was related to the extent of disease at presentation and to therapy. No deaths occurred after 15 months and no recurrences occurred after 13 months after diagnosis. Six of eight stage IE patients (75%) and nine of 29 stage IIE patients (31%) have survived a minimum of 2 years; one of the three stage IVE patients has survived 17 years. Unfavorable prognostic findings at surgery were serosal involvement, presence of tumor at the surgical margins, mesenteric nodal involvement, and the presence of abdominal fluid or blood. Paraortic nodal involvement or multiple primary foci were universally fatal. Eight of 11 patients (73%) treated with surgery and whole abdominal irradiation (greater than or equal 2000 rad) with or without chemotherapy have survived. Seven of 18 patients (39%) treated with surgery and low dose chemotherapy have survived. One of seven patients treated with surgery and localized or low dose radiation therapy with or without chemotherapy has survived. Four patients treated with surgery alone died. Bone marrow and central nervous system involvement occurred after previous disease relapse elsewhere.
1948年至1974年间，共收治40例局限性可切除肠非霍奇金淋巴瘤患儿。生存率与就诊时疾病的范围及治疗有关。诊断后15个月内无死亡病例，13个月后无复发病例。8例ⅠE期患者中有6例（75%）、29例ⅡE期患者中有9例（31%）至少存活了2年；3例ⅣE期患者中有1例存活了17年。手术时不良的预后表现为浆膜受累、手术切缘有肿瘤、肠系膜淋巴结受累以及存在腹水或血性腹水。主动脉旁淋巴结受累或多个原发灶均为致死性。11例接受手术及全腹照射（大于或等于2000拉德）加或不加化疗的患者中有8例（73%）存活。18例接受手术及低剂量化疗的患者中有7例（39%）存活。7例接受手术及局部或低剂量放疗加或不加化疗的患者中有1例存活。4例仅接受手术治疗的患者死亡。骨髓和中枢神经系统受累发生在先前其他部位疾病复发之后。
