体内P388白血病模型在天然产物抗肿瘤活性评估中的稳定性。
Stability of the in vivo P388 leukemia model in evaluation of antitumor activity of natural products.
作者信息
Marsh J C, Shoemaker R H, Suffness M
出版信息
Cancer Treat Rep. 1985 Jun;69(6):683-5.
PMID:4016772
Abstract
The stability of the P388 mouse leukemia model over 15 years was examined. Eleven natural products and one synthetic compound (5-FU) tested repetitively under the same conditions of dose and schedule were associated with no significant change in their activity. The P388 model, used in conjunction with other in vivo and in vitro tumor models, continues to be of value in the anticancer drug screening process.
摘要
研究了P388小鼠白血病模型在15年中的稳定性。在相同剂量和给药方案条件下重复测试的11种天然产物和1种合成化合物（5-氟尿嘧啶），其活性无显著变化。P388模型与其他体内和体外肿瘤模型联合使用，在抗癌药物筛选过程中仍然具有价值。
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