Zheng Wenlian, Lai Wenxiu, Zhang Yixun, Wang Xiaoxiang, Yang Kaibo, Zhou Xin, Chen Zheng, Yang Ronghua, Deng Liaoyuan
Department of Burn and Wound Repair, Shaoguan First People's Hospital, No. 3 Dongdi South Road, Zhenjiang, Shaoguan, Guangdong, 512000, China.
Department of Urology, Yuebei People's Hospital, No. 133 Huimin South Road, Wujiang, Shaoguan, Guangdong, 512026, China.
Arch Dermatol Res. 2025 Apr 1;317(1):656. doi: 10.1007/s00403-025-04101-5.
Individuals with type 2 diabetes mellitus (T2DM) not only face the risk of difficult wound healing after trauma or surgery but also struggle with scar formation after wound healing. However, the relationship between T2DM and hypertrophic scars (HS) remains unclear. First, the data sets related to T2DM and HS were downloaded from the OpenGWAS database. Second, the inverse variance-weighted (IVW) technique was employed to assess the causal impact of T2DM on HS utilizing mendelian randomization (MR). Finally, sensitivity analyses and reverse MR analyses were performed to determine the robustness of the findings and to examine the potential for reverse causation. A positive causal relationship between T2DM and HS was observed. Three suitable datasets for T2DM analysis were obtained using the ids ebi-a-GCST006867, ebi-a-GCST007515, and ebi-a-GCST007516 (A total of 206,572 cases and 753,191 controls were included). The HS (finn-b-L12_HYPETROPHICSCAR) dataset comprised 766 cases and 207,482 controls. The IVW model results showed odds ratio (OR) of 1.213 (95% confidence interval (CI): 1.04-1.41, p = 0.0137), 1.300 (95% CI: 1.05-1.61, p = 0.017), and 1.284 (95% CI: 1.03-1.60, p = 0.0276), respectively. The analysis results were stable without any significant bias or reverse causality. This study systematically explored the causal relationship between T2DM and the risk of HS for the first time, and provided a quantitative effect assessment. The results showed consistency, which indicated the potential biological mechanism and clinical intervention direction.
2型糖尿病（T2DM）患者不仅面临创伤或手术后伤口愈合困难的风险，而且在伤口愈合后还会面临瘢痕形成的问题。然而，T2DM与增生性瘢痕（HS）之间的关系仍不清楚。首先，从OpenGWAS数据库下载了与T2DM和HS相关的数据集。其次，采用逆方差加权（IVW）技术，利用孟德尔随机化（MR）评估T2DM对HS的因果影响。最后，进行敏感性分析和反向MR分析，以确定研究结果的稳健性，并检验反向因果关系的可能性。观察到T2DM与HS之间存在正因果关系。使用ids ebi-a-GCST006867、ebi-a-GCST007515和ebi-a-GCST007516获得了三个适合T2DM分析的数据集（共纳入206,572例病例和753,191例对照）。HS（finn-b-L12_HYPETROPHICSCAR）数据集包括766例病例和207,482例对照。IVW模型结果显示比值比（OR）分别为1.213（95%置信区间（CI）：1.04-1.41，p = 0.0137）、1.300（95%CI：1.05-1.61，p = 0.017）和1.284（95%CI：1.03-1.60，p = 0.0276）。分析结果稳定，无任何显著偏差或反向因果关系。本研究首次系统探讨了T2DM与HS风险之间的因果关系，并提供了定量效应评估。结果显示具有一致性，这表明了潜在的生物学机制和临床干预方向。
