Dexeus F, Logothetis C J, Samuels M L, Hossan E, von Eschenbach A C
Cancer Treat Rep. 1985 Jul-Aug;69(7-8):885-6.
Thirty-nine patients with metastatic prostate cancer refractory to hormonal manipulation were treated with vinblastine by continuous infusion. The dose was 1.5 mg/m2 daily for 5 days. A 21% response rate was obtained. Eight patients, two with visceral metastasis, one with nodal disease, and five with osseous metastasis achieved objective response. The median duration of response was 28 weeks. Myelosuppression was the major side effect: the median leukocyte count nadir was 2.8 X 10(3)/ml and the median platelet count nadir was 184 X 10(3)/ml.
39例对激素治疗无效的转移性前列腺癌患者接受了长春碱持续静脉输注治疗。剂量为每日1.5mg/m²，共5天。有效率为21%。8例患者获得客观缓解，其中2例有内脏转移，1例有淋巴结转移，5例有骨转移。缓解的中位持续时间为28周。骨髓抑制是主要副作用：白细胞计数最低点的中位数为2.8×10³/ml，血小板计数最低点的中位数为184×10³/ml。
