Feng Sujuan, Lin Yanfeng, Wang Rong, Fang Xingxing, Shi Jiaqi, Gu Xiameng, Yu Yang
Department of Nephrology, Affiliated Hospital 2 of Nantong University, Nantong, 226000, China.
Hemodialysis center, Affiliated Haimen Hospital of Xinglin College, Nantong University, Nantong, 226000, China.
Int Urol Nephrol. 2025 Apr 1. doi: 10.1007/s11255-025-04469-3.
This study aimed to examine the relationship between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and cognitive impairment (CI) in patients with chronic kidney disease (CKD).
A total of 125 patients with CKD treated in the Department of Nephrology, The Second Affiliated Hospital of Nantong University from July 2022 to May 2023 were selected and divided into observation group (44 patients with CI) and control group (81 patients with normal cognitive function). Multivariate logistic regression analysis was performed to analyze the risk factors of CI, and Spearman rank correlation analysis was used to analyze the correlation between serum Lp-PLA2 and Montreal Cognitive Assessment Scale (MoCA) score. The truncation value of Lp-PLA2 in CKD patients with CI was analyzed by receiver operating characteristic curve (ROC).
Serum Lp-PLA2 levels were significantly elevated in the observation group compared to the control group (P < 0.05). The area under the ROC curve for Lp-PLA2 was 0.849, with a cutoff value of 232 ng/mL for identifying CI in patients with CKD. Lp-PLA2 levels were independently associated with CI in patients with CKD (odds ratio [OR] = 0.988, 95% confidence interval [CI]: 0.982-0.993, P < 0.001).
Elevated serum Lp-PLA2 levels serve as an independent risk factor for CI in patients with CKD.
本研究旨在探讨慢性肾脏病（CKD）患者血清脂蛋白相关磷脂酶A2（Lp-PLA2）水平与认知障碍（CI）之间的关系。
选取2022年7月至2023年5月在南通大学第二附属医院肾内科治疗的125例CKD患者，分为观察组（44例CI患者）和对照组（81例认知功能正常患者）。采用多因素logistic回归分析CI的危险因素，采用Spearman等级相关分析血清Lp-PLA2与蒙特利尔认知评估量表（MoCA）评分的相关性。通过受试者工作特征曲线（ROC）分析CKD合并CI患者Lp-PLA2的截断值。
观察组血清Lp-PLA2水平显著高于对照组（P＜0.05）。Lp-PLA2的ROC曲线下面积为0.849，识别CKD患者CI的截断值为232 ng/mL。Lp-PLA2水平与CKD患者的CI独立相关（比值比[OR]=0.988，95%置信区间[CI]：0.982-0.993，P＜0.001）。
血清Lp-PLA2水平升高是CKD患者发生CI的独立危险因素。
