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移植后急性髓系白血病的免疫逃逸

Immune Escape of Acute Myeloid Leukemia after Transplantation.

作者信息

Ho Nguyen Huong Jenny Giang, Talvard-Balland Nana, Köhler Natalie, Zeiser Robert

机构信息

Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Freiburg University Medical Center, Freiburg, Germany.

CIBSS - Centre for Integrative Biological Signaling Studies, Freiburg, Germany.

出版信息

Blood Cancer Discov. 2025 May 5;6(3):168-181. doi: 10.1158/2643-3230.BCD-24-0063.

DOI:10.1158/2643-3230.BCD-24-0063
PMID:40168448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12050969/
Abstract

We discuss the mechanisms of AML immune evasion including loss or downregulation of MHC class I and II, reduced TRAIL receptor expression, inhibitory metabolite production, inhibitory ligand expression, impaired proinflammatory cytokine production, and AML niche alterations.

摘要

我们讨论了急性髓系白血病（AML）免疫逃逸的机制，包括主要组织相容性复合体（MHC）I类和II类的缺失或下调、肿瘤坏死因子相关凋亡诱导配体（TRAIL）受体表达降低、抑制性代谢产物产生、抑制性配体表达、促炎细胞因子产生受损以及AML微环境改变。

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Immune Escape of Acute Myeloid Leukemia after Transplantation.移植后急性髓系白血病的免疫逃逸
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2
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本文引用的文献

1
Current Trends and Outcomes in Cellular Therapy Activity in the United States, Including Prospective Patient-Reported Outcomes Data Collection in the Center for International Blood and Marrow Transplant Research Registry.美国细胞治疗活动的当前趋势与成果，包括国际血液和骨髓移植研究中心登记处对患者前瞻性报告结果的数据收集。
Transplant Cell Ther. 2024 Sep;30(9):917.e1-917.e12. doi: 10.1016/j.jtct.2024.06.021. Epub 2024 Jun 27.
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Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice.癌基因诱导 TIM-3 配体表达决定了小鼠对 TIM-3 治疗的敏感性。
J Clin Invest. 2024 Jun 25;134(16):e177460. doi: 10.1172/JCI177460.
3
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment.致癌性钙网蛋白通过刺激骨髓微环境中转化生长因子β的表达和调节性T细胞的扩增诱导免疫逃逸。
Cancer Res. 2024 Sep 16;84(18):2985-3003. doi: 10.1158/0008-5472.CAN-23-3553.
4
Comprehensive characterization of IFNγ signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies.全面表征 IFNγ 信号在急性髓系白血病中的作用揭示了预后和治疗策略。
Nat Commun. 2024 Feb 28;15(1):1821. doi: 10.1038/s41467-024-45916-6.
5
Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation-Immune signature correlates with response.异基因造血细胞移植后复发的急性髓系白血病患者使用去甲基化药物联合纳武单抗的II期试验——免疫特征与疗效相关
Br J Haematol. 2023 Oct;203(2):264-281. doi: 10.1111/bjh.19007. Epub 2023 Aug 4.
6
The role of the MDM2/p53 axis in antitumor immune responses.MDM2/p53 轴在抗肿瘤免疫反应中的作用。
Blood. 2024 Jun 27;143(26):2701-2709. doi: 10.1182/blood.2023020731.
7
Sorafenib maintenance after allogeneic haemopoietic stem-cell transplantation in patients with FLT3-ITD acute myeloid leukaemia: long-term follow-up of an open-label, multicentre, randomised, phase 3 trial.异基因造血干细胞移植后索拉非尼维持治疗 FLT3-ITD 急性髓系白血病患者：一项开放标签、多中心、随机、3 期临床试验的长期随访。
Lancet Haematol. 2023 Aug;10(8):e600-e611. doi: 10.1016/S2352-3026(23)00117-5. Epub 2023 Jul 3.
8
Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation.异基因造血细胞移植后通过遗传免疫逃逸导致白血病复发。
Nat Commun. 2023 May 31;14(1):3153. doi: 10.1038/s41467-023-38113-4.
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Cancer Cell. 2023 Mar 13;41(3):490-504. doi: 10.1016/j.ccell.2023.02.009. Epub 2023 Mar 2.
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TIGIT blockade repolarizes AML-associated TIGIT M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.TIGIT 阻断使 AML 相关的 TIGIT M2 巨噬细胞重新极化至 M1 表型，并增加 CD47 介导的吞噬作用。
J Immunother Cancer. 2022 Dec;10(12). doi: 10.1136/jitc-2022-004794.