Ahmadi Ali, Hosseinzadeh Rahman, Ghani Milad, Mohadjerani Maryam
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Food Chem. 2025 Jul 30;481:144020. doi: 10.1016/j.foodchem.2025.144020. Epub 2025 Mar 24.
In this study, a chemically modified cellulose paper was developed as a thin film microextraction (TFME) device to extract the fungicides tebuconazole and propiconazole from fruit samples (orange, kiwi, apple and lemon). The modification was achieved with tetracarboxylic acid azo-calix[4]arene using toluene diisocyanate as a linker and characterized by FT-IR, TGA, FE-SEM and XRD. The modified cellulose paper showed high affinity for the target compounds, with a linear response from 1 to 200 μg L. It achieved low limits of detection (0.29 μg L for tebuconazole and 0.26 μg L for propiconazole) and quantification, with intra-day and inter-day precision (%RSDs below 4.58 %). The findings revealed that cellulose paper with azo-calix[4]arene tetracarboxylic acid exhibited several advantages over alternative techniques, including enhanced sensitivity, high selectivity for propiconazole and tebuconazole, cost-effectiveness, and environmental sustainability. The extraction process is also more stable and allows the detection of lower concentrations of these compounds in fruit samples.
在本研究中，开发了一种化学改性纤维素纸作为薄膜微萃取（TFME）装置，用于从水果样品（橙子、猕猴桃、苹果和柠檬）中萃取杀菌剂戊唑醇和丙环唑。使用甲苯二异氰酸酯作为连接剂，通过四羧酸偶氮杯[4]芳烃实现改性，并通过傅里叶变换红外光谱（FT-IR）、热重分析（TGA）、场发射扫描电子显微镜（FE-SEM）和X射线衍射（XRD）进行表征。改性纤维素纸对目标化合物表现出高亲和力，在1至200μg/L范围内呈线性响应。它实现了低检测限（戊唑醇为0.29μg/L，丙环唑为0.26μg/L）和定量限，日内和日间精密度（相对标准偏差%RSDs低于4.58%）。研究结果表明，具有四羧酸偶氮杯[4]芳烃的纤维素纸相对于其他技术具有多个优点，包括增强的灵敏度、对丙环唑和戊唑醇的高选择性、成本效益以及环境可持续性。萃取过程也更稳定，能够检测水果样品中更低浓度的这些化合物。
