抗体编号方案：抗体工程的进展、比较及工具

Antibody numbering schemes: advances, comparisons and tools for antibody engineering.

作者信息

Zhu Zirui, Ashrafian Hossein, Tabrizi Navid Mohammadian, Matas Emily, Girard Louisa, Ma Haowei, Nice Edouard C

机构信息

Department of Chemistry and Biochemistry, The Ohio State University, 151 W. Woodruff Ave. Columbus, OH 43210, United States of America.

Chemistry Graduate Program, The Ohio State University, 151 W. Woodruff Ave. Columbus, OH 43210, United States of America.

出版信息

Protein Eng Des Sel. 2025 Jan 10;38. doi: 10.1093/protein/gzaf005.

DOI:10.1093/protein/gzaf005

PMID:40169149

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11997657/

Abstract

The evolution of antibody engineering has significantly enhanced the development of antibody-based therapeutics, enabling the creation of novel antibody formats tailored for specific applications. Since the introduction of the Kabat numbering scheme in 1977, various schemes have been developed and modified, forming the foundation for multiple antibody engineering projects. The tools associated with these schemes further facilitate the engineering process. However, discrepancies among current numbering schemes can lead to confusion. This study examines various numbering schemes and related tools, providing new insights into antibody variable domains. Improved understanding of antibody numbering and related tools holds significant potential for more precise and efficient antibody design, thereby advancing antibody-based therapeutics and diagnostics.

摘要

抗体工程的发展显著推动了基于抗体的治疗药物的开发，使得能够创建针对特定应用量身定制的新型抗体形式。自1977年引入卡巴特编号方案以来，已开发并修改了各种方案，为多个抗体工程项目奠定了基础。与这些方案相关的工具进一步促进了工程过程。然而，当前编号方案之间的差异可能会导致混淆。本研究考察了各种编号方案及相关工具，为抗体可变结构域提供了新的见解。更好地理解抗体编号及相关工具对于更精确、高效的抗体设计具有巨大潜力，从而推动基于抗体的治疗和诊断发展。