Shen Qifei, Gao Kai, Zhang Peijuan, Zhao Zhiqin, Gao Anran, Xu Yanzi, Chen Chao, Chen Kai, Meng Lingjie, Wang Heng, Zhang Mingming, Dang Dongfeng
School of Chemistry, Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi'an Key Laboratory of Sustainable Polymer Materials, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
J Med Chem. 2025 Apr 10;68(7):7780-7791. doi: 10.1021/acs.jmedchem.5c00380. Epub 2025 Apr 1.
Highly emissive metallacages that generate reactive oxygen species (ROS) are important to synergistic cancer therapy, but it is still challenging to balance the emission and phototheranostic properties. Herein, a metallacage of DTPABT-Mc is prepared. It is observed that emission in the near-infrared region from 600 to 1000 nm with a high photoluminescence quantum yield value of 7.92% in solids is recorded for DTPABT-Mc. In addition, the ability to produce both type I and type II ROS under light irradiation is also observed, leading to potential application in photodynamic therapy (PDT) and chemotherapy. After that, 4T1@DTPABT-Mc-NPs, covering DTPABT-Mc nanoparticles with 4T1 cell membranes, are prepared to enhance their tumor-targeting ability. This finally results in effective therapeutic performance , effectively inhibiting tumor growth. These results suggest that DTPABT-Mc-NPs exhibit excellent synergistic therapeutic effects by combining PDT and chemotherapy, providing new ideas to design agents for diagnosis and therapy in the future.
能够产生活性氧（ROS）的高发射性金属笼对协同癌症治疗很重要，但平衡发射和光诊疗特性仍具有挑战性。在此，制备了一种DTPABT-Mc金属笼。观察到DTPABT-Mc在固体中在600至1000nm的近红外区域发射，其光致发光量子产率高达7.92%。此外，还观察到其在光照下产生I型和II型ROS的能力，使其在光动力疗法（PDT）和化疗中有潜在应用。之后，制备了用4T1细胞膜包覆DTPABT-Mc纳米颗粒的4T1@DTPABT-Mc-NPs，以增强其肿瘤靶向能力。这最终产生了有效的治疗效果，有效抑制了肿瘤生长。这些结果表明，DTPABT-Mc-NPs通过结合PDT和化疗表现出优异的协同治疗效果，为未来设计诊断和治疗药物提供了新思路。
