Firouzi Faegheh, Ramezani Tehrani Fahimeh, Shaharki Hojat, Mousavi Maryam, Moradi Nahid, Saei Ghare Naz Marzieh
Tehran Medical Branch, Islamic Azad University, Tehran 19395-1495, Iran.
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Tehran, Iran.
J Endocr Soc. 2025 Mar 14;9(5):bvaf043. doi: 10.1210/jendso/bvaf043. eCollection 2025 May.
The association between blood parameters and gestational diabetes (GDM) is of renewed interest. Some blood cell parameters are assumed to be associated with GDM.
This meta-analysis was performed to assess the association of hematological indices in the first trimester of pregnancy and later development of GDM.
A comprehensive database search, including PubMed, Web of Science, Epistemonikos, Scopus, Scientific Information Database, and Magiran, was conducted to identify potential peer-reviewed publications. The PECO framework was applied to evaluate the eligibility of all included studies. Standardized mean differences (95% CI), were calculated. Additionally, pooled odds ratios, summary estimates of sensitivity and specificity, positive and negative likelihood ratios, and diagnostic odds ratios (DOR) were determined.
The meta-analysis encompassed 33 studies involving a total of 247 107 pregnant women. Compared to control groups, GDM groups exhibited statistically significantly higher hemoglobin levels (standard mean difference: 0.50, 95% CI: 0.39-0.62), red blood cell (RBC) (0.23, 0.15-0.32), and hematocrit (0.44, 0.34-0.55). The pooled adjusted estimate (aOR:1.02, 1.006-1.03) indicated that the hemoglobin levels were significantly associated with an increased risk of GDM. GDM groups had significantly higher platelet count (0.280, 0.16-0.39) and white blood cells (WBC) counts, as well as (0.482, 0.377-0.58), lymphocytes (0.12, 0.025-0.22), neutrophils (0.541:0.404-0.679), and neutrophil-lymphocyte ratio (0.31, 0.20-0.43). In distinguishing women with GDM from the control group, the DOR was found to be 3.21 for the hemoglobin and 2.94 for the mean platelet volume.
Higher levels of RBC, platelet, and WBC counts during the first trimester of pregnancy were observed in women who subsequently developed GDM compared to control groups.
血液参数与妊娠期糖尿病（GDM）之间的关联再次受到关注。一些血细胞参数被认为与GDM有关。
进行这项荟萃分析以评估妊娠早期血液学指标与GDM后期发生之间的关联。
进行了全面的数据库检索，包括PubMed、科学网、Epistemonikos、Scopus、科学信息数据库和Magiran，以识别潜在的同行评审出版物。应用PECO框架评估所有纳入研究的 eligibility。计算标准化均值差（95%CI）。此外，还确定了合并比值比、敏感性和特异性的汇总估计值、阳性和阴性似然比以及诊断比值比（DOR）。
该荟萃分析涵盖33项研究，共涉及247107名孕妇。与对照组相比，GDM组的血红蛋白水平（标准化均值差：0.50，95%CI：0.39 - 0.62）、红细胞（RBC）（0.23，0.15 - 0.32）和血细胞比容（0.44，0.34 - 0.55）在统计学上显著更高。合并调整估计值（aOR：1.02，1.006 - 1.03）表明血红蛋白水平与GDM风险增加显著相关。GDM组的血小板计数（0.280，0.16 - 0.39）和白细胞（WBC）计数以及（0.482，0.377 - 0.58）、淋巴细胞（0.12，0.025 - 0.22）、中性粒细胞（0.541:0.404 - 0.679）和中性粒细胞与淋巴细胞比值（0.31，0.20 - 0.43）显著更高。在区分患有GDM的女性与对照组时，发现血红蛋白的DOR为3.21，平均血小板体积的DOR为2.94。
与对照组相比，随后发生GDM的女性在妊娠早期的红细胞、血小板和白细胞计数水平更高。
