Botto Inês, Serrazina Juliana, Freitas Carlos Rodrigues, Carvalhana Sofia, Nogueira-Costa Gonçalo, Cortez-Pinto Helena
Serviço de Gastrenterologia e Hepatologia, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.
Serviço de Oncologia, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.
GE Port J Gastroenterol. 2024 Jul 26;32(2):134-138. doi: 10.1159/000539093. eCollection 2025 Apr.
Hepatocellular carcinoma (HCC) is a highly vascular malignancy with the potential for intravascular invasion. However, vascular extension into the cardiac chambers is extremely rare.
We present a 25-year-old male patient in whom the investigation of a cardiac murmur led to the discovery of an intracardiac mass that proved to be advanced-stage HCC with vascular invasion of the right heart. The patient had a previously unknown non-cirrhotic chronic hepatitis B virus (HBV) infection. Despite antiviral therapy and systemic treatment for HCC, he eventually died about 1 month later due to disease progression.
This report highlights the importance of early HBV diagnosis and treatment for timely detection and management of HCC. Advanced-stage HCC, particularly with cardiac involvement, has an extremely poor prognosis.
肝细胞癌（HCC）是一种血管丰富的恶性肿瘤，具有血管内侵袭的可能性。然而，血管延伸至心腔极为罕见。
我们报告一名25岁男性患者，对其心脏杂音进行检查时发现心内肿块，经证实为晚期HCC伴右心血管侵犯。该患者既往有未知的非肝硬化慢性乙型肝炎病毒（HBV）感染。尽管接受了抗病毒治疗和HCC的全身治疗，但他最终因疾病进展在约1个月后死亡。
本报告强调了早期HBV诊断和治疗对于及时发现和管理HCC的重要性。晚期HCC，尤其是累及心脏者，预后极差。
