Liu Yu-Ling, Mei Yue-Ming, Xun Jing-Qiong, Lv Zhuo-Yue, He Qian, Liu Zhou-Bo-Ran, Li Lin, Xie Fen, Dai Ru-Chun
National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Department of Endocrinology and Metabolism, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha 410005, Hunan, China.
Bone Rep. 2025 Mar 10;25:101834. doi: 10.1016/j.bonr.2025.101834. eCollection 2025 Jun.
Bone remodeling process is the basis for maintaining normal bone microstructure and promoting fracture repair. Recent studies have proven that integrins can promote bone formation and fracture repair. Integrin-linked kinase (ILK), as the proximal effector of the integrin receptor, is a key protein factor linking integrin and cytoskeleton. It is involved in crucial cellular processes including proliferation, survival, differentiation, migration, invasion, and angiogenesis reflects on systemic changes in the kidney, heart, muscle, skin, and vascular system. At present, the regulation effect of ILK in bone formation attracts the attention of researchers. This review emphasizes that ILK as a key molecule affects the functions of bone marrow stromal cells (BMSCs) and osteoblasts, and regulates bone formation. Additionally, ILK plays a key role in the process of"angiogenic-osteogenic coupling ". The present role of ILK in the pathogenesis of osteoporosis is also described. Strategies that target ILK may as a new prospective treatment for osteoporosis (OP).
骨重塑过程是维持正常骨微结构和促进骨折修复的基础。最近的研究已证明整合素可促进骨形成和骨折修复。整合素连接激酶（ILK）作为整合素受体的近端效应器，是连接整合素与细胞骨架的关键蛋白因子。它参与包括增殖、存活、分化、迁移、侵袭和血管生成等关键细胞过程，反映在肾脏、心脏、肌肉、皮肤和血管系统的系统性变化中。目前，ILK在骨形成中的调节作用引起了研究人员的关注。本综述强调ILK作为关键分子影响骨髓间充质干细胞（BMSC）和成骨细胞的功能，并调节骨形成。此外，ILK在“血管生成 - 骨生成偶联”过程中起关键作用。还描述了ILK在骨质疏松症发病机制中的当前作用。靶向ILK的策略可能成为骨质疏松症（OP）的一种新的前瞻性治疗方法。
