Zhen Ling-Ling, Hou Ming-Tong, Wang Sheng-Bao
The Second Hospital of Lanzhou University, Lanzhou730030, China.
The Second Clinical Medical College of Lanzhou University, Lanzhou730030, China.
J Asian Nat Prod Res. 2025 Apr 2:1-15. doi: 10.1080/10286020.2025.2481291.
Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).
红景天苷是一种具有抗炎和抗氧化等多种药理活性的中药，而急性肾损伤（AKI）是一种常见的脓毒症诱导的急性炎症反应。本研究采用转录组学与代谢组学相结合的方法，确定花生四烯酸代谢相关的铁死亡是红景天苷改善脓毒症诱导的急性肾损伤（SI-AKI）的重要机制。
