儿童和青少年中衰老及认知相关甲基化谱评分在两个时间点的稳定性
Stability of Aging- and Cognition-Related Methylation Profile Scores Across Two Waves in Children and Adolescents.
作者信息
deSteiguer Abby J, Raffington Laurel, Sabhlok Aditi, Tanksley Peter, Tucker-Drob Elliot M, Harden K Paige
机构信息
Department of Psychology, University of Texas at Austin, Austin, Texas, USA.
Max Planck Research Group Biosocial-Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.
出版信息
Child Dev. 2025 May-Jun;96(3):1189-1206. doi: 10.1111/cdev.14239. Epub 2025 Apr 2.
DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (M between waves = 2.41 years) from N = 407 participants (M = 12.05 years, 51% female, 60% White), test-retest correlations were estimated for four salivary MPSs related to aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), and cognitive function (Epigenetic-g). MPSs varied in longitudinal stability (test-retest rs = 0.38 to 0.76). MPSs did not differ in children exposed to the COVID-19 pandemic, but race-ethnic and sex differences were apparent. Further research is necessary to understand which environmental perturbations impact DNA-methylation trajectories and when children are most sensitive to those impacts.
DNA甲基化谱评分（MPSs）可对与终身身体和认知健康相关的生物学特征进行索引，但目前缺乏关于其在儿童期纵向稳定性的信息。利用2014年至2022年收集的两波数据（两波之间的时间间隔M = 2.41年），来自N = 407名参与者（平均年龄M = 12.05岁，51%为女性，60%为白人），对与衰老（PhenoAgeAccel、GrimAgeAccel、DunedinPACE）和认知功能（Epigenetic - g）相关的四种唾液MPSs进行了重测相关性估计。MPSs在纵向稳定性方面存在差异（重测相关系数rs = 0.38至0.76）。在接触过新冠疫情的儿童中，MPSs没有差异，但种族和性别差异明显。有必要进行进一步研究，以了解哪些环境干扰会影响DNA甲基化轨迹，以及儿童在何时对这些影响最为敏感。
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