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长效土霉素治疗牛慢性嗜皮菌病的疗效:病例报告

Chronic Form of Dematophilosis Treatment Response With Long-Acting Oxytetracycline in Cattle: Case Report.

作者信息

Hordofa Negessa Diriba, Sori Teshale, Befekadu Bethel

机构信息

School of Veterinary Medicine, Ambo University, Ambo, Ethiopia.

College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.

出版信息

Vet Med Sci. 2025 May;11(3):e70339. doi: 10.1002/vms3.70339.

Abstract

Dermatophilosis is dermatitis with acute, subacute and chronic courses which is usually exudative and rarely proliferative and can affect cattle, sheep, goats and horses and sometimes in humans. A 5-year-old local breed bull was presented to Professor Feseha Gebreab Memorial Veterinary Teaching Hospital of the College of Veterinary Medicine and Agriculture, Addis Ababa University, with main complaints of dry skin lesions which started before one year of presentation. Upon clinical examination, the bull was in good body condition, and there was a dry scabby skin lesion on its dorsum and ventral parts. Impression smear was made from the beneath scabs, and staining was done by Giemsa. The examined smear revealed typical railroad stack arrangements of organisms by the staining. The skin lesion was scrubbed with 10% sodium chloride solution; lesions were removed and disinfected with cetrimide 3% and chlorhexidine 0.3% (Cavlon) solution. Iodine 2% was applied topically for 5 successive days. The bull was treated with seven doses of long-acting oxytetracycline (20%) deep intramuscular injection at a dose of 20 mg/kg for 7 days. After a treatment course of 5 weeks, the removed crusts re-emerged again and the disease was not responsive to the given drug. The severity of the lesion might be the cause of disease relapse, and individual animal factors could have influenced the treatment's resistive response and it need further study to determine whether oxytetracycline is beneficial in treating chronic dermatophilosis.

摘要

皮肤嗜皮菌病是一种具有急性、亚急性和慢性病程的皮炎,通常有渗出液,很少增生,可感染牛、绵羊、山羊和马,有时也会感染人类。一头5岁的本地品种公牛被送到亚的斯亚贝巴大学兽医学院的费塞哈·格布雷亚布纪念兽医教学医院,主要症状是在就诊前一年就开始出现的皮肤干燥病变。临床检查时,这头公牛身体状况良好,其背部和腹部有干燥结痂的皮肤病变。从痂皮下制作了压片涂片,并用吉姆萨染色。检查的涂片经染色后显示出典型的菌体“铁路堆栈”排列。用10%氯化钠溶液擦洗皮肤病变;清除病变并用3%的西曲溴铵和0.3%的洗必泰(凯弗隆)溶液进行消毒。连续5天局部涂抹2%碘液。给这头公牛深部肌肉注射七剂长效土霉素(20%),剂量为20毫克/千克,持续7天。经过5周的治疗疗程后,脱落的痂皮再次出现,且疾病对所用药物无反应。病变的严重程度可能是疾病复发的原因,个体动物因素可能影响了治疗的抵抗反应,需要进一步研究以确定土霉素是否对治疗慢性皮肤嗜皮菌病有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/11962754/b045f9bb2650/VMS3-11-e70339-g001.jpg

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