C反应蛋白与白蛋白比值与扁平苔藓的关联。
The association of C-reactive protein to albumin ratio wıth lichen planus.
作者信息
Ataş Hatice, Atak Tuğba, Kartal Selda Pelin, Tas Aygar Gamze
机构信息
University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Dermatology and Venereology - Ankara, Turkey.
Ministry of Health Islahiye State Hospital, Dermatology Clinic - Gaziantep, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2025 Mar 31;71(2):e20241166. doi: 10.1590/1806-9282.20241166. eCollection 2025.
OBJECTIVE
In some diseases associated with inflammation, the C-reactive protein-to-albumin ratio can be used as a biomarker of inflammation. Since lichen planus is a chronic inflammatory disease, our study aimed to investigate the relationship between C-reactive protein-to-albumin ratio and disease activity and whether it plays a role in determining disease prognosis, and compare them with those in subjects without lichen planus.
METHODS
This is a case-control study. Demographic data, clinical features, and laboratory measures, including neutrophil, lymphocyte, eosinophil, platelet counts, neutrophile-to-lymphocyte ratio, erythrocyte sedimentation rate, C-reactive protein, albumin, and C-reactive protein-to-albumin ratio were statistically compared between patients with lichen planus (n=61) and controls (n=64).
RESULTS
Albumin and erythrocyte sedimentation rate (p<0.001), C-reactive protein (p=0.017), C-reactive protein-to-albumin ratio (p=0.016), and neutrophile-to-lymphocyte ratio (p=0.02) were significantly higher in the patient group than in the control group. C-reactive protein-to-albumin ratio (p=0.003, OR 1.2), neutrophile-to-lymphocyte ratio (p=0.02, OR 1.4), and erythrocyte sedimentation rate (p=0.003, OR 1.1) were effective in differentiating patients from the healthy group. Erythrocyte sedimentation rate>4.5 mm/h, C-reactive protein-to-albumin ratio>0.6, and neutrophile-to-lymphocyte ratio>1 were useful in showing disease activity, of which C-reactive protein-to-albumin ratio has the best value with 92% sensitivity. C-reactive protein-to-albumin ratio has a sensitivity of 100% and is more effective and sensitive than other markers in distinguishing between mild and severe groups and between single and multiple involvement.
CONCLUSION
Elevated C-reactive protein-to-albumin ratio levels may be considered a potential marker for lichen planus. It may be highly sensitive to follow-up of systemic inflammation and disease activity in patients with lichen planus. However, further prospective studies may confirm the association between C-reactive protein-to-albumin ratio and lichen planus.
目的
在一些与炎症相关的疾病中，C反应蛋白与白蛋白比值可作为炎症的生物标志物。由于扁平苔藓是一种慢性炎症性疾病，我们的研究旨在探讨C反应蛋白与白蛋白比值与疾病活动度之间的关系，以及它在确定疾病预后中是否起作用，并将其与无扁平苔藓的受试者进行比较。
方法
这是一项病例对照研究。对扁平苔藓患者（n=61）和对照组（n=64）的人口统计学数据、临床特征和实验室指标进行统计学比较，包括中性粒细胞、淋巴细胞、嗜酸性粒细胞、血小板计数、中性粒细胞与淋巴细胞比值、红细胞沉降率、C反应蛋白、白蛋白以及C反应蛋白与白蛋白比值。
结果
患者组的白蛋白、红细胞沉降率（p<0.001）、C反应蛋白（p=0.017）、C反应蛋白与白蛋白比值（p=0.016）以及中性粒细胞与淋巴细胞比值（p=0.02）均显著高于对照组。C反应蛋白与白蛋白比值（p=0.003，OR 1.2）、中性粒细胞与淋巴细胞比值（p=0.02，OR 1.4）以及红细胞沉降率（p=0.003，OR 1.1）在区分患者与健康组方面有效。红细胞沉降率>4.5 mm/h、C反应蛋白与白蛋白比值>0.6以及中性粒细胞与淋巴细胞比值>1有助于显示疾病活动度，其中C反应蛋白与白蛋白比值的价值最佳，敏感性为92%。C反应蛋白与白蛋白比值的敏感性为100%，在区分轻度和重度组以及单发性和多发性受累方面比其他标志物更有效、更敏感。
结论
C反应蛋白与白蛋白比值升高可能被视为扁平苔藓的潜在标志物。它可能对扁平苔藓患者的全身炎症和疾病活动度的随访高度敏感。然而，进一步的前瞻性研究可能会证实C反应蛋白与白蛋白比值与扁平苔藓之间的关联。
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