血清素受体（5HTR2A）和多巴胺受体（DRD2）基因多态性在精神分裂症患者利培酮所致体重增加和高泌乳素血症中的预测作用 - Suppr

Predictive Role of Serotonin Receptor (5HTR2A) and Dopamine Receptor (DRD2) gene polymorphisms in risperidone-induced weight gain and hyperprolactinemia in patients with schizophrenia.

作者信息

Goud Alladi Charanraj, Rajkumar Ravi Philip, Shewade Deepak Gopal, Goenka Luxitaa, Srinivasamurthy Suresh Kumar

机构信息

Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Hněvotínská 1333/5, 77900, Olomouc, Czech Republic.

Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

出版信息

Eur J Clin Pharmacol. 2025 Jun;81(6):899-905. doi: 10.1007/s00228-025-03835-5. Epub 2025 Apr 2.

DOI:10.1007/s00228-025-03835-5

PMID:40172663

Abstract

摘要

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Predictive Role of Serotonin Receptor (5HTR2A) and Dopamine Receptor (DRD2) gene polymorphisms in risperidone-induced weight gain and hyperprolactinemia in patients with schizophrenia.血清素受体（5HTR2A）和多巴胺受体（DRD2）基因多态性在精神分裂症患者利培酮所致体重增加和高泌乳素血症中的预测作用

Eur J Clin Pharmacol. 2025 Jun;81(6):899-905. doi: 10.1007/s00228-025-03835-5. Epub 2025 Apr 2.

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J Pharmacol Pharmacother. 2017 Jan-Mar;8(1):28-32. doi: 10.4103/jpp.JPP_197_16.

Hyperprolactinemia in Children and Adolescents with Use of Risperidone: Clinical and Molecular Genetics Aspects.使用利培酮的儿童和青少年高催乳素血症：临床和分子遗传学方面

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Relation between serum prolactin levels and antipsychotic response to risperidone in patients with schizophrenia.精神分裂症患者血清催乳素水平与利培酮抗精神病反应的关系。

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Dopamine (DRD2) and Serotonin (HTR2A, 2C) Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia.多巴胺（DRD2）和5-羟色胺（HTR2A、2C）受体基因多态性不影响南印度精神分裂症患者对利培酮的早期反应。

Fundam Clin Pharmacol. 2019 Jun;33(3):355-364. doi: 10.1111/fcp.12424. Epub 2018 Nov 21.

Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms.精神分裂症患者抗精神病药物所致锥体外系症状：与多巴胺及5-羟色胺受体和转运体基因多态性的关联

Eur J Clin Pharmacol. 2007 Mar;63(3):233-41. doi: 10.1007/s00228-006-0234-8. Epub 2007 Jan 17.

Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents.多巴胺D2受体基因变异与儿童及青少年中利培酮所致高催乳素血症

Pharmacogenet Genomics. 2009 May;19(5):373-82. doi: 10.1097/FPC.0b013e328329a60f.

Allele and genotype frequencies of serotonin and dopamine transporter and receptor polymorphisms in a Norwegian population.挪威人群中血清素和多巴胺转运体及受体多态性的等位基因和基因型频率。

Genet Test Mol Biomarkers. 2011 Jul-Aug;15(7-8):557-63. doi: 10.1089/gtmb.2010.0210. Epub 2011 Mar 31.

Association study of schizophrenia with polymorphisms at six candidate genes.精神分裂症与六个候选基因多态性的关联研究。

Schizophr Res. 2001 Apr 15;49(1-2):65-71. doi: 10.1016/s0920-9964(00)00106-7.

Potential link between genetic polymorphisms of and dopamine receptors and treatment efficacy of risperidone on schizophrenia.[基因名称]与多巴胺受体的基因多态性之间的潜在联系以及利培酮对精神分裂症的治疗效果

Neuropsychiatr Dis Treat. 2017 Dec 5;13:2935-2943. doi: 10.2147/NDT.S148824. eCollection 2017.

本文引用的文献

Risperidone Decreases Expression of Serotonin Receptor-2A (5-HT2A) and Serotonin Transporter (SERT) but Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs from Patients with Schizophrenia.利培酮降低精神分裂症患者外周血单核细胞中5-羟色胺受体2A（5-HT2A）和5-羟色胺转运体（SERT）的表达，但不影响多巴胺受体和多巴胺转运体（DAT）的表达。

Pharmaceuticals (Basel). 2024 Jan 28;17(2):167. doi: 10.3390/ph17020167.

Metabolic biomarkers of risperidone-induced weight gain in drug-naïve patients with schizophrenia.初治精神分裂症患者中利培酮所致体重增加的代谢生物标志物。

Front Psychiatry. 2023 Apr 20;14:1144873. doi: 10.3389/fpsyt.2023.1144873. eCollection 2023.

The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain.非典型抗精神病药利培酮通过作用于下丘脑黑皮质素 4 受体引起体重增加。

J Exp Med. 2021 Jul 5;218(7). doi: 10.1084/jem.20202484. Epub 2021 May 12.

Genetic Polymorphisms of Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia.精神分裂症患者受体的基因多态性与抗精神病药物所致代谢功能障碍

J Pers Med. 2021 Mar 5;11(3):181. doi: 10.3390/jpm11030181.

Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5-HT2c receptor-NPY pathway.利培酮通过下丘脑弓状核 5-HT2c 受体-NPY 途径刺激摄食并诱导体重增加。

CNS Neurosci Ther. 2020 May;26(5):558-566. doi: 10.1111/cns.13281. Epub 2019 Dec 27.

Serotonin 5-HT, 5-HT and dopamine D receptors strongly influence prefronto-hippocampal neural networks in alert mice: Contribution to the actions of risperidone.血清素 5-HT、5-HT 和多巴胺 D 受体强烈影响警觉状态下小鼠的前额叶-海马神经网络：对利培酮作用的贡献。

Neuropharmacology. 2019 Nov 1;158:107743. doi: 10.1016/j.neuropharm.2019.107743. Epub 2019 Aug 17.

Fundam Clin Pharmacol. 2019 Jun;33(3):355-364. doi: 10.1111/fcp.12424. Epub 2018 Nov 21.

Management of common adverse effects of antipsychotic medications.抗精神病药物常见不良反应的管理。

World Psychiatry. 2018 Oct;17(3):341-356. doi: 10.1002/wps.20567.

Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia.精神分裂症的内在及抗精神病药物诱导的代谢功能障碍

Front Neurosci. 2017 Jul 28;11:432. doi: 10.3389/fnins.2017.00432. eCollection 2017.

J Pharmacol Pharmacother. 2017 Jan-Mar;8(1):28-32. doi: 10.4103/jpp.JPP_197_16.

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Predictive Role of Serotonin Receptor (5HTR2A) and Dopamine Receptor (DRD2) gene polymorphisms in risperidone-induced weight gain and hyperprolactinemia in patients with schizophrenia.

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