Mayengbam Shyamchand, Raman Maitreyi, Parnell Jill A, Eksteen Bertus, Lambert Jennifer E, Eller Lindsay K, Nicolucci Alissa C, Aktary Michelle L, Reimer Raylene A
Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada.
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Eur J Nutr. 2025 Apr 2;64(4):144. doi: 10.1007/s00394-025-03660-7.
Our aim was to examine the effects of combined prebiotic fiber supplementation and weight loss counseling on liver fat, body composition, subjective appetite, serum metabolomics, and intestinal microbiota in adults with MASLD.
In a double blind, placebo-controlled trial, adult participants aged 18-70 years old with MASLD were randomized to receive prebiotic (oligofructose-enriched inulin, 16 g/day; n = 22) or isocaloric placebo (maltodextrin; n = 20) for 24 weeks alongside weight loss counseling from a registered dietitian. Primary outcomes were change in intrahepatic fat % (IHF%) and hepatic injury from baseline to 24 weeks. Secondary outcomes included body composition, subjective appetite, serum lipids and cytokines, fecal microbiota, and serum metabolomics.
At baseline, participants had IHF of 14.4 ± 8.4%. The change in IHF from baseline to 24 weeks did not differ between prebiotic and placebo. Prebiotic participants had a greater decrease (p = 0.029) in percent trunk fat compared to placebo. Compared to placebo, prebiotic significantly decreased desire to eat and hunger ratings over the course of the intervention. Fecal microbiota analysis showed a significant increase in Bifidobacterium abundance with prebiotic. A pathway analysis based on untargeted serum metabolomics revealed a downregulation of taurine and hypotaurine metabolism in the placebo group which was conserved in the prebiotic group.
Adding prebiotic fiber supplementation to weight loss counseling for adults with MASLD enhanced reductions in trunk fat and had a beneficial effect on subjective appetite compared to placebo. Improvements in fecal microbial profile and taurine metabolism revealed specific beneficial effects of prebiotics in the management of MASLD.
Clinicaltrials.gov/study/NCT02568605.
我们的目的是研究联合补充益生元纤维和体重减轻咨询对患有非酒精性脂肪性肝病（MASLD）的成年人肝脏脂肪、身体成分、主观食欲、血清代谢组学和肠道微生物群的影响。
在一项双盲、安慰剂对照试验中，年龄在18至70岁之间患有MASLD的成年参与者被随机分配接受益生元（富含低聚果糖的菊粉，16克/天；n = 22）或等热量安慰剂（麦芽糊精；n = 20），为期24周，同时接受注册营养师的体重减轻咨询。主要结局是从基线到24周肝内脂肪百分比（IHF%）的变化和肝损伤。次要结局包括身体成分、主观食欲、血清脂质和细胞因子、粪便微生物群和血清代谢组学。
在基线时，参与者的IHF为14.4±8.4%。益生元和安慰剂组从基线到24周的IHF变化没有差异。与安慰剂相比，益生元组参与者的躯干脂肪百分比下降幅度更大（p = 0.029）。与安慰剂相比，在干预过程中，益生元显著降低了进食欲望和饥饿评分。粪便微生物群分析显示，益生元使双歧杆菌丰度显著增加。基于非靶向血清代谢组学的通路分析显示，安慰剂组中牛磺酸和亚牛磺酸代谢下调，而益生元组中则保持不变。
与安慰剂相比，在患有MASLD的成年人的体重减轻咨询中添加益生元纤维补充剂可增强躯干脂肪的减少，并对主观食欲产生有益影响。粪便微生物谱和牛磺酸代谢的改善揭示了益生元在MASLD管理中的特定有益作用。
Clinicaltrials.gov/study/NCT02568605。
