Jiang Rongtao, Geha Paul, Rosenblatt Matthew, Wang Yunhe, Fu Zening, Foster Maya, Dai Wei, Calhoun Vince D, Sui Jing, Spann Marisa N, Scheinost Dustin
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06510, USA.
Sci Adv. 2025 Apr 4;11(14):eadt1083. doi: 10.1126/sciadv.adt1083. Epub 2025 Apr 2.
Chronic pain conditions frequently coexist and share common genetic vulnerabilities. Despite evidence showing associations between pain and depression, the additive effect of co-occurring pain conditions on depression risk and the underlying mechanisms remain unclear. Leveraging data from 431,038 UK Biobank participants with 14-year follow-up, we found a significantly increased risk of depression incidence in individuals reporting pain, irrespective of body site or duration (acute or chronic), compared with pain-free individuals. The depression risk increased with the number of co-occurring pain sites. Mendelian randomization supported potential causal inference. We constructed a composite pain score by combining individual effects of acute or chronic pain conditions across eight body sites in a weighted manner. We found that depression risks increased monotonically in parallel with composite pain scores. Moreover, some inflammatory markers, including C-reactive protein, partially mediated the association between composite pain scores and depression risk. Considering the high prevalence of comorbid depression and pain, pain screening may help identify high-risk individuals for depression.
慢性疼痛状况常常同时存在并具有共同的遗传易感性。尽管有证据表明疼痛与抑郁症之间存在关联，但并发疼痛状况对抑郁风险的累加效应及其潜在机制仍不清楚。利用来自431,038名英国生物银行参与者的14年随访数据，我们发现，与无疼痛个体相比，报告有疼痛的个体，无论疼痛部位或持续时间（急性或慢性）如何，抑郁症发病风险显著增加。抑郁风险随着并发疼痛部位数量的增加而升高。孟德尔随机化支持了潜在的因果推断。我们通过以加权方式综合八个身体部位急性或慢性疼痛状况的个体效应，构建了一个复合疼痛评分。我们发现抑郁风险与复合疼痛评分呈平行的单调增加。此外，一些炎症标志物，包括C反应蛋白，部分介导了复合疼痛评分与抑郁风险之间的关联。考虑到共病抑郁症和疼痛的高患病率，疼痛筛查可能有助于识别抑郁症的高危个体。
