Dash Pranjyan, Thirumurugan Senthilkumar, Chen Yen-Lin, Dhawan Udesh, Lin Yu-Chien, Lin Ching-Po, Liu Wai-Ching, Tseng Ching-Li, Chung Ren-Jei
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan.
Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glasgow G116EW, UK.
Int J Pharm. 2025 Apr 30;675:125545. doi: 10.1016/j.ijpharm.2025.125545. Epub 2025 Mar 31.
Administration of therapeutic strategies alongside magnetic multifunctional nanocomposites has displayed improved cancer prognosis. However, the clinical use of this combination is limited owing to poor bioimaging performance, low biocompatibility, restricted tissue penetration in ultraviolet/visible regions, and low therapeutic efficacy of nanocomposites. To overcome these existing challenges, we designed iron oxide (FeO)-based upconversion nanoparticles (UCNPs). FeO nanoparticles were synthesized via facile solvothermal method and incorporated into mesoporous silica (mS) layer (FeO@mS). FeO@mS nanoparticles were further decorated onto the surface of the UCNPs as a core material (UCNP-FeO@mS, FMUP). Methotrexate (MTX) an efficient anticancer drug was loaded onto the mesoporous silica to produce FMUP-MTX nanocomposite. The FMUP nanocomposite displayed excellent photothermal therapy and showed 43% photothermal conversion efficiency. The designed nanocomposite has ability to decompose HO to generates hydroxyl radical that promote chemodynamic therapy effect due to attribution of Fenton reaction. FMUP-MTX nanocomposite possessed improved chemotherapeutic performance under NIR laser irradiation. Further, T-weighted magnetic resonance imaging performance of nanocomposite was observed. In vitro studies shown that cell viability was decreased to 25% under laser irradiation due to the therapeutic effect. In vivo studies exhibited that the FMUP-MTX nanocomposite inhibited the tumor growth with the laser irradiation. Therefore, these nanocomposites can be considered as a promising candidate for cancer therapeutics treatment.
将治疗策略与磁性多功能纳米复合材料联合使用已显示出改善的癌症预后。然而，由于生物成像性能差、生物相容性低、在紫外/可见光区域的组织穿透受限以及纳米复合材料的治疗效果低，这种组合的临床应用受到限制。为了克服这些现有挑战，我们设计了基于氧化铁（FeO）的上转换纳米颗粒（UCNPs）。通过简便的溶剂热法合成了FeO纳米颗粒，并将其掺入介孔二氧化硅（mS）层（FeO@mS）中。将FeO@mS纳米颗粒作为核心材料进一步修饰到UCNPs的表面（UCNP-FeO@mS，FMUP）。将高效抗癌药物甲氨蝶呤（MTX）负载到介孔二氧化硅上，制备出FMUP-MTX纳米复合材料。FMUP纳米复合材料表现出优异的光热疗法，光热转换效率达43%。所设计的纳米复合材料能够分解H₂O₂以产生羟基自由基，由于芬顿反应的作用，促进了化学动力学治疗效果。FMUP-MTX纳米复合材料在近红外激光照射下具有改善的化疗性能。此外，还观察到了该纳米复合材料的T加权磁共振成像性能。体外研究表明，由于治疗效果，激光照射下细胞活力降至25%。体内研究表明，FMUP-MTX纳米复合材料在激光照射下抑制了肿瘤生长。因此，这些纳米复合材料可被视为癌症治疗的有前途的候选材料。
