Kerr J C, Hobson R W, Seelig R F, Swan K G
Gastroenterology. 1977 Mar;72(3):474-8.
Inferior mesenteric arterial blood flow was measured with an electromagnetic blood flowmeter in five anesthetized rhesus monkeys. The effects of vasopressin on this vasculature were determined to evaluate the optimal, safe concentration of this agent during its clinical application in the management of hemorrhagic lesions of the colon. Control flow was 29 +/- 3 (SE) ml min-1; aortic pressure was 124 +/- 4 mm Hg. Intraarterial injections of vasopressin, in doses ranging logarithmically from 5 X 10(-5) to 5 X 10(-2) U kg-1, caused dose-dependent decreases in flow. At the highest dose, vasopressin reduced flow by 50% and increased arterial pressure by 9 mm Hg. When infused, at a rate of 5 X 10(-3) U kg-1 min-1, vasopressin produced a significant and sustained reduction in inferior mesenteric arterial blood flow. Autoregulatory escape was not observed. At this rate, vasopressin increased arterial pressure 10 mm Hg, by the 6th minute of infusion. This hypertension was unaccompanied by significant bradycardia. After cessation of the infusion, flow gradually returned to control values over a period of minutes. These observations indicate that vasopressin is a potent constrictor in the inferior mesenteric arterial circulation of the monkey, and support the use of this agent to control lower intestinal bleeding in man. At a dose of 5 X 10(-3) U kg-1 min-1, vasopressin causes a significant reduction in flow without adverse systemic side effects.
用电磁血流计在五只麻醉的恒河猴身上测量肠系膜下动脉血流量。测定血管加压素对该血管系统的作用，以评估该药物在临床应用于治疗结肠出血性病变时的最佳安全浓度。对照血流量为29±3（标准误）ml·min⁻¹；主动脉压为124±4 mmHg。动脉内注射血管加压素，剂量从5×10⁻⁵到5×10⁻² U·kg⁻¹呈对数变化，导致血流量呈剂量依赖性减少。在最高剂量时，血管加压素使血流量减少50%，动脉压升高9 mmHg。当以5×10⁻³ U·kg⁻¹·min⁻¹的速率输注时，血管加压素使肠系膜下动脉血流量显著且持续减少。未观察到自动调节逃逸现象。以该速率输注时,在输注第6分钟时血管加压素使动脉压升高10 mmHg。这种高血压未伴有明显的心动过缓。输注停止后，血流量在几分钟内逐渐恢复到对照值。这些观察结果表明，血管加压素在猴的肠系膜下动脉循环中是一种有效的血管收缩剂，并支持在人类中使用该药物来控制下消化道出血。在剂量为5×10⁻³ U·kg⁻¹·min⁻¹时，血管加压素可使血流量显著减少，且无不良全身副作用。
